E11 Bio - Spatial ‘Omics Scientist

E11 Bio - Spatial Omics Scientist

E11 Bio is on a mission to unlock whole-brain mammalian connectomics. Were a collaborative and interdisciplinary team of scientists and engineers developing an innovative technology platform for scalable brain mapping. E11 Bio is a non-profit focused research organization organized under the Convergent Research umbrella and located in Alameda, California. We are pursuing ambitious neuroscience research and operating like a nimble start-up while organized as a non-profit. Read our technology roadmap for more.

Position

E11 Bio is seeking a creative and passionate spatial omics scientist to co-develop next-generation technology for high-throughput connectomic imaging using molecular barcodes. As a core member of the E11 team, youll develop innovative methods for highly-multiplexed imaging of protein barcodes at the scale of mammalian brains. Working closely with world experts in cellular barcoding and computational connectomic reconstruction, youll design spatial omics and barcode detection experiments, collect, analyze, and interpret multiplexed image data, and present or publish open scientific results for public benefit.

Responsibilities

• Develop proteomics methods (e.g. based on oligo-conjugated antibodies) for highly multiplexed detection of antibodies in expansion microscopy using combinatorial imaging.
• Develop robust signal amplification methods (e.g. rolling circle amplification, hybridization chain reaction) for detection of protein-based cellular barcodes and molecular markers at proteomic scale in swellable hydrogels.
• Design probe sets and combinatorial imaging experiments (e.g., in situ sequencing, MERFISH) compatible with expansion microscopy to detect cell barcodes in brain tissue.
• Integrate and apply automatic liquid handling and automatic fluorescence imaging methods in a robust and reproducible pipeline.
• Process and analyze multiplexed image volumes, including stitching and registration across imaging cycles, and feature detection, decoding and classification.
• Work closely with experimental and computational scientists at E11 and through external partnerships to collaboratively design experiments, analyze experimental data, and interpret results.
• Maintain excellent laboratory notebook practices, prepare reports and manuscripts, and present results internally and externally, and source new techniques from the scientific community.

Required Qualifications

Preferred Qualifications

You will love this job if

We offer

Scientist I

Base salary range : $82,000 to $123,000 annually

Bonus : Performance-based, up to 20% of base salary

Total potential compensation : $98,400 - $147,600 annually

Scientist II

Base salary range : $94,000 to $141,000

Bonus : Performance-based, up to 20% of base salary

Total potential compensation : $112,800 - $169,200 annually

Offers are normally made at the lower portion of the range, enabling employee growth within the range over time. Scientist I positions normally require 0-3 years of post-PhD or equivalent industry experience; Scientist II positions normally require 3-6 years of post-PhD or equivalent industry experience. Final base pay for a given candidate may differ based on factors such as prior experience, education and training, market trends, and skillset, and additional qualifications. The listed range refers to salary only. The total compensation package also includes a health and wellness stipend, matched 401K contributions, corporate holidays, flexible employee vacation, and other benefits.

E11 Bio, LLC is an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other basis protected by applicable local, state, or federal laws or prohibited by Company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.

$82,000 - $141,000 a year

Compensation details : 82000-141000 Yearly Salary

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