Research Scientist I

Position Description :

In the role of Research Scientist I you will supervise and independently perform studies to advance the goals of the principal investigator's research projects. Develop, plan and implement experiments, analyze data and compile results, monitor quality control processes to ensure integrity of research, and prepare and write manuscripts and grant applications.

This role will be in the laboratory of Dr. William Drobyski in the Departments of Medicine and Microbiology at the Medical College of Wisconsin that is focused on transplantation immunology with a specific emphasis on the immunobiology of allogeneic bone marrow transplantation and the pathophysiology of acute and chronic graft versus host disease (GVHD). Other areas of interest emanating from this focus include T cell and regulatory T cell biology along with inflammation induced by innate immune cells (macrophages, microglia, and dendritic cells).

Specific areas of interest include inflammatory cytokine networks that contribute to GVHD, inflammatory cytokine signaling and regulatory pathways that impact the development of tolerance, modulate anti-leukemic responses, and induce pathological damage particularly within the gastrointestinal tract and central nervous system using genetically modified mouse models, flow cytometry, q-PCR, RNA-seq, western blot, single cell RNA seq, bioinformatics, and other immunological techniques. Recent publications include Blood 2018; 132(4) : 435-447, Nature Communications 2018; 9(1) : 5037; Blood 2020; 135(8) : 568-581, Blood 2021; 137(9) : 1241-1255, Blood Advances 2022; 6(9) : 2791-2803 and Nature Communications 2023; 14(1) : 7963.

Primary Functions

• Perform immunology experiments from design conception to final data analysis and presentation of results.
• Collect, analyze and provide summations of data from experiments. Perform all necessary calculations and reduction of data errors to allow for interpretation of all experimental outcomes.
• Prepare scientific papers, present scientific data at local and national meetings and assist the Principal Investigator in the preparations of grant applications.
• Perform molecular biological assays using RT-PCR, real time PCR, Western and molecular cloning techniques. Adopt new techniques in laboratory.
• Coordinate research study activities; lead and manage projects. Assist in developing, implementing and monitoring quality activities.
• Participate in meetings with principle investigator and research staff and evaluate / interpret the validity of data, develop methodologies, evaluate lab procedures.
• Perform and develop routine and complex computational and database methods for implementation. May serve as primary statistician for area.
• May oversee the work of laboratory personnel including training and development as well as daily work direction / delegation / prioritizing. Participate in teaching other lab staff to achieve experimental and educational goals.
• Maintain supplies, may negotiate with vendors, and track purchase orders. Other work-related duties as assigned and appropriate.

Knowledge - Skills - Abilities

Preferred Schedule :

Full-time role with expectations for coverage during core business hours and flexibility required as necessary to accommodate business needs.

Position Requirements :

Specifications

Minimum Required Education : PhD in a scientific field

Minimum Required Experience : No prior experience required

Preferred Experience : Immunology, including mouse models, flow cytometry and / or molecular biology, Research skills include immunology, molecular and cellular biology techniques

Why MCW?

For a full list of positions see : www.mcw.edu / careers

For a brief overview of our benefits see : departments / human-resources / benefits

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The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering an inclusive community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity / expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants, or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.