Research Scholar, Engineering Non-Coding Genome in Immune Cells (Immunogenomics Group - Biohub NY)

The Team

CZ Biohub New York will first harness the natural capabilities of our immune cells to detect and fix abnormalities in our bodies at very early stages. It will then bioengineer immune cells to create new capabilities to detect and potentially treat events before they lead to untreatable disease.

CZ Biohub New York is part of the CZ Biohub Network, a group of nonprofit research institutes created and supported by the Chan Zuckerberg Initiative.

Our Vision

• We pursue large scientific challenges that cannot be pursued in conventional environments
• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at the CZ Biohub Network facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub Network and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

The Laboratory of Immunogenomics at CZ Biohub NY studies the non-coding regulatory genome to understand and address immune dysfunction in diseases like cancer, autoimmune disorders, and aging. We focus on enhancers—non-coding, highly cell–type–specific transcriptional regulatory elements—and their role in shaping immune responses. We develop and utilize genomic technologies, including bulk and single-cell nascent RNA sequencing, genome editing, immune engineering, and CRISPR-based functional screens in patient biopsies, organoid systems, and mouse models. Through computational analysis integrating machine learning and AI, we map enhancer–gene networks and identify disease-driving elements. Our goal is to advance enhancer-guided precision genomic medicine for diseases involving immune dysfunction.

We are seeking a highly motivated Research Scholar to lead pioneering research into the functional mapping and engineering of non-coding regulatory elements that govern immune cell gene expression. This role will focus on identifying and manipulating enhancers, silencers, and other cis-regulatory elements that control immune-modulating genes (cytokines, chemokines, checkpoint regulators) to reprogram immune responses in health and disease.

The successful candidate will integrate advanced functional genomics, single-cell multi-omics, and synthetic biology approaches to dissect immune regulatory circuits, engineer precise expression control in immune cell subsets, and apply these strategies in in vivo models and human-derived immune organoid systems. This is a unique opportunity to operate at the intersection of genomics, immunology, and bioengineering in a collaborative, multidisciplinary environment.

What You'll Do

What You'll Bring

Essential –

Nice to have –

Compensation

The New York, NY base pay range for a new hire in this role is $85,000.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.

Benefits for the Whole You

We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.

If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

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