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Associate Scientist - Protein Sciences
Associate Scientist - Protein SciencesCrossbow Therapeutics, Inc. • Cambridge, MA, US
Associate Scientist - Protein Sciences

Associate Scientist - Protein Sciences

Crossbow Therapeutics, Inc. • Cambridge, MA, US
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Job Description

Job Description

Crossbow Therapeutics is seeking a highly motivated and detail-oriented Associate Scientist - Protein Sciences to join our Antibody Development Team in Cambridge, MA. This individual will contribute to the development and characterization of therapeutic antibodies for both therapeutic applications and research initiatives. This role provides the opportunity to work collaboratively with cross-functional teams to produce, purify, and analytically characterize antibodies and fusion proteins. The ideal candidate will possess a solid foundation in biochemistry or a related field, along with hands-on experience in protein analytical techniques, production, and purification. If you are passionate about protein science and eager to make a significant contribution, this role offers a dynamic opportunity to contribute to innovative therapeutic developments.

Essential Duties and Responsibilities :

  • Design, develop, and implement sophisticated analytical methods using HPLC, binding affinity using BLI instrument, and ELISA for the characterization of antibodies.
  • Conduct comprehensive analyses to assess protein purity and quality using SDS-PAGE, UV / Vis spectroscopy, HPLC tools, and other relevant analytical methods.
  • Execute protein production using mammalian expression systems (e.g., CHO, HEK293) and purification processes for recombinant monoclonal and bispecific antibodies, and other proteins.
  • Utilize a variety of chromatography techniques, including affinity, ion exchange, size exclusion, and hydrophobic interaction chromatography.
  • Support cell-based assay, such as cytotoxicity and cytokine evaluation.
  • Operate and maintain AKTA FPLC systems and analytical HPLC instruments to ensure efficient workflow.
  • Address and resolve technical challenges that arise in protein analytical and purification workflows, ensuring high-quality results.
  • Document and maintain precise records of laboratory activities using an electronic laboratory notebook (Benchling) and communicate findings clearly through written reports and presentations.
  • Actively stay informed about advancements in protein analytical, production, and purification technologies to continuously enhance methodologies.
  • Provide technical and resourcing support to other functional groups as needed.

Requirements

  • Bachelor's degree + 6 years with relevant experience, Master's + 3 years with relevant experience, or Ph.D. in Biochemistry, Molecular Biology, or a related field.
  • Proven hands-on experience with multiple mammalian expression platforms (CHO and HEK293 cells) required
  • Demonstrated track record with analytical development of proteins and antibodies is required.
  • Validated technical understanding and applied technical expertise to develop, optimize, and troubleshoot methods key assays across drug development, including HPLC and UPLC instruments
  • Extensive experience with AKTA instrumentation, in various purification techniques (e.g., affinity, ion exchange, HIC, SEC) as well as protein quality control methods.
  • This position requires on-site work 5 days per week at our office in Harvard Square, Cambridge, Massachusetts.

    • Additional Knowledge, Skills and Abilities

  • Experience with therapeutic antibody developability assessments is a plus.
  • Excellent problem-solving skills complemented by keen attention to detail.
  • Ability to thrive both independently and collaboratively in a fast-paced environment.
  • Flexibility to adapt to changing plans.
  • Strong communication and organizational skills to support effective teamwork.

    • The Benefits of Working at Crossbow

  • We offer a competitive compensation that includes an annual discretionary bonus and equity package, allowing you to have a stake in our long-term success.
  • Take care of your physical and mental health through our subsidized medical, dental and vision insurance programs
  • Enjoy work and life with our flexible paid time off program, annual holidays including a Winter Break and sick time
  • Utilize our tuition reimbursement program to further your education
  • Maximize your future retirement by participating in our 401k program
  • Expected salary for an Associate Scientist is commensurate with experience within the range below :

    • About Crossbow

    Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets. Crossbow’s efficient and selective approach is designed to target the entire universe of cancer proteins, dramatically expanding the potential of antibody therapy to address many types of cancer.

    Crossbow Therapeutics is proud to be an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace where every individual is respected and valued. We recognize that diversity fuels innovation and enhances our capacity to achieve meaningful outcomes through our work.

    Note to Recruiters : Please be aware that we do not accept unsolicited resumes and kindly request that you do not contact our team regarding this job posting. If a resume is submitted to a Crossbow team member without a prior agreement, we will not be obligated to pay any referral or placement fees.

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    Associate Scientist • Cambridge, MA, US