Senior Program Manager (San Francisco)

About Probably Genetic

Probably Genetic is changing the lives of patients living with severe, complex diseases. Our data platform is used by drug developers and patient advocacy groups to develop and launch treatments for these patients. Our technology discovers undiagnosed patients online, analyzes their disease state using machine learning and at-home testing, and enables compliant communication with patients. In doing so, we help patients access diagnoses, clinical trials, and treatments as early as possible.

We are a tight-knit group of hard-working, ambitious problem solvers united by a mission greater than ourselves. We do well by doing right by patients. We are developing some of the most cutting-edge solutions in healthcare, and our roadmap is packed with innovations in bioinformatics, AI, and drug development. We have built a lean, all-star team to help us bring our vision to life, and we want you to be a part of it.

Probably Genetic has raised multiple rounds of funding from Silicon Valley's best investors, including Threshold, Khosla, and Y Combinator, and offer competitive salaries, comprehensive benefits, and meaningful early stage equity.

About the Role

We are seeking a proactive, strategic, and operationally-minded Senior Program Manager who will be responsible for the execution, delivery, and cross-functional coordination of our genetic disease programs. This role sits at the intersection of our internal teams and client delivery, ensuring programs are well-researched, expertly planned, and flawlessly executed to meet both patient impact and client expectations.

What You'll Do

Lead Cross-Functional Program Delivery : Drive end-to-end program delivery from research through completion, serving as the central coordinator across ML, growth, business development, and operations teams. Manage complex timelines, dependencies, and cross-functional resources to deliver exceptional outcomes for biotech and pharmaceutical clients.

• Opportunities for automation : Program offer generation, progress reporting, completion insights, internal communications via Slack / Zapier
• Opportunities for creative human intervention : Strategic problem-solving for implementation challenges, leading operational decision-making, translating automated insights into actionable strategies

Build Strategic Client Partnerships : Act as the primary client liaison, facilitating seamless execution and translating complex scientific needs into actionable internal plans. Maintain the highest standards of professionalism while representing company values.

Champion Patient-Centered Scientific Excellence : Leverage deep disease area expertise to inform program strategy and delivery. Collaborate with patient advocacy groups, researchers, and key opinion leaders to amplify patient voices and drive meaningful outcomes.

Design Scalable Operations & Quality Systems : Design scalable processes that balance automation efficiency with scientific rigor. Develop SOPs, risk mitigation frameworks, and quality control systems that ensure consistent, high-caliber deliverables.

Drive Business Impact Through Data-Driven Insights : Partner with business development to translate contracts into executable scientific programs. Provide data-driven insights on program outcomes to optimize future offerings and demonstrate ROI to stakeholders. Partner with CEO on key special projects that propel the business towards the next phase of growth.

Who You Are

We are looking for a few specific things that will help you succeed in this role :

Some things that are not required, but you will learn on the job :

As with all new hires at Probably Genetic, you will also need to be :

The salary range for this role is $112,000-$155,000 annually. Actual compensation offered will depend on several factors including but not limited to : work experience, education, skill level, and / or other business and organizational needs.

What We Offer At Probably Genetic

Probably Genetic is committed to fostering a welcoming and inclusive work environment for people of all genders, sexuality, ethnicity, socioeconomic background and life experiences. We urge candidates of all backgrounds to apply. If you require specific accommodations as you interview or consider working with us, please let us know.