Computational modeling and high-density microelectrode array analysis forne

Job Title : Computational modeling and high-density microelectrode array analysis forne

Job Number : 105308

Location : Sacramento, US

RESEARCH FOCUS

The Ben-Shalom laboratory investigates neurodevelopmental disorders (NDDs) using a multiscale approach integrating high-density microelectrode array (HD-MEA) recordings with biophysically detailed computational modeling. Our research focuses on understanding how genetic mutations alter neuronal excitability and network dynamics, leading to epilepsy and other NDDs. The candidate will develop and validate in silico neuronal models using empirical data from HD-MEA recordings to bridge single-neuron biophysics with circuit-level dysfunction and identify therapeutic targets.

RESPONSIBILITIES

• Computational Modeling : Develop biophysically detailed neuronal models using NEURON, NetPyNE, and Python / MATLAB
• HD-MEA Data Analysis : Process HD-MEA recordings including spike sorting and network characterization
• Model Validation : Integrate experimental data to validate computational models
• Network Simulations : Simulate cortical networks to predict mutation effects and identify therapeutic interventions
• Data Integration : Combine multi-scale data with computational predictions using statistical and ML approaches
• Research Dissemination : Prepare manuscripts and present at conferences

QUALIFICATIONS

RESEARCH ENVIRONMENT

APPOINTMENT DETAILS

Competitive salary commensurate with NIH postdoctoral scales and experience. Excellent career development opportunities with potential for renewal based on performance and funding. Review of applications begins immediately and continues until filled.

Application Deadline : 2026-03-05

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