Postdoctoral Scholar

Our laboratory is seeking a full-time postdoctoral research fellow who is motivated, enthusiastic, and enjoys collaborative and independent science. The laboratory focuses on translational eye research involving age-related macular degeneration (AMD), AAV gene therapy, CRISPR gene editing, and ophthalmic imaging, including unique opportunities for highly translational nonhuman primate research. You will be involved in state-of-the-art technologies that will be important in large animal models and regenerative medicine research. Our laboratory pioneered rhesus macaques as nonhuman primate models of AMD, the first use of CRISPR-based genome editing to treat neovascular AMD, and the use of suprachoroidal microneedles for AAV-mediated gene delivery.

Successful candidates will become part of a highly successful and collaborative interdisciplinary team of junior and senior investigators, including clinician-scientists, retinal biologists, veterinary ophthalmologists, and imaging bioengineers at UC Davis. As a motivated, successful clinician-scientist faculty, I am strongly committed to mentoring the candidate for either academic or industry positions.

Responsibilities :

Responsibilities of this position will include planning, execution, and presentation of experiments involving :

Basic molecular biology, protein biochemistry, and cell culture techniques.

Preparation of biological and chemical reagents.

Bioinformatics with multi-omic data (e.g. scRNA-seq, metabolomics, proteomics, etc.).

AAV gene therapy and CRISPR-Cas9 gene editing (design & delivery).

Rodent and nonhuman primate (NHP) studies including ocular injections, dissections, and histology.

Ocular imaging technologies : OCT, SLO, adaptive optics .

Collaborate with bioengineers in ocular imaging and optogenetics.

Shared lab duties, such as ordering and maintaining lab supplies; maintaining compliance.

Requirements :

• Highly motivated, organized, and responsible individual with excellent communication skills.
• Doctoral degree in biological science (Ph.D. or MD / Ph.D.)
• Ability to work and troubleshoot independently.
• Previous laboratory experience (1 to 3 years).
• Experience with retinal research and / or bioinformatics skills involving single-cell or spatial transcriptomics or other multiomic technologies are preferred but not required.

The qualified candidate will have earned a doctoral degree in cell biology, developmental biology, neurobiology, or a closely related field must provide proof of U.S. citizenship or current eligibility to work in the United States. This is a full-time appointment, with occasional weekend hours for the management of experiments. A 2-year minimum commitment is required.

More information about the principal investigator and lab can be found at : https : / / health.ucdavis.edu / eyecenter / yiulab / index.html. The laboratory is located in Tupper Hall in the UC Davis campus. Candidates should send a letter of interest, including a one-page cover letter

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