Principal Scientist, ASO Biologist

Description

About GondolaBio

GondolaBio is a clinical-stage biopharmaceutical company focused on developing next-generation therapeutics for genetic diseases. Originally launched as BridgeBioX, a subsidiary of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. The company aims to leverage cutting-edge biological research to create breakthrough medicines addressing high unmet needs across multiple therapeutic areas, including neurology, pulmonology, cardiology, nephrology, and endocrinology. Located on the Stanford Life Sciences campus, GondolaBio fosters a unique hybrid environment where top scientists from around the world collaborate with senior leadership and advisors, blending industry expertise with academic innovation.

Who you are

We're seeking an entrepreneurial scientific leader who combines intellectual rigor with practical execution skills to advance our antisense oligonucleotide (ASO) pipeline at GondolaBio. You will serve as a scientific lead for multiple preclinical ASO programs which will involve collaboration with the n-Lorem foundation. You will play a pivotal role in designing, executing, and interpreting experiments. This position offers the opportunity to shape research strategy while mentoring junior scientists and contributing to a growing, interdisciplinary team.

Requirements

Key Responsibilities

• Serve as a subject matter expert for ASO discovery, design, and preclinical evaluation across multiple programs
• Lead the design and execution of in vitro studies across multiple preclinical programs using the ASO modality
• Develop and optimize functional assays and disease models (e.g., iPSC-derived and patient primary cell-derived) to support target engagement and efficacy assessments
• Perform and interpret molecular, protein, and functional analyses (e.g., qPCR, Western blot), integrating findings with in vivo and translational data
• Design and interpret in vivo efficacy, safety, and target engagement experiments for ASOs in multiple indications
• Supervise and mentor junior scientists, fostering a high-performing and collaborative research environment
• Oversee external research activities, including CRO and academic collaborations, ensuring high-quality and timely data delivery
• Stay abreast of emerging science, engage with external experts, and represent the company at scientific meetings
• Communicate results and strategic insights to senior leadership; contribute to publications and IP
• Partner with leadership to shape and execute a cohesive research strategy that advances program objectives across discovery and translational stages

Education, Experience, & Skills Requirements

No matter your role at GondolaBio, successful team members are :

What We Offer

The base pay range for this position is $190,000 to $205,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.

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