Clinical Modeling & Analytics Innovation Lead

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians.  If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

This position is based in Northbrook, Illinois. Remote work from certain states may be permitted in accordance with Astellas’ Responsible Flexibility Guidelines. Candidates interested in remote work are encouraged to apply.

Purpose and Scope :

The Clinical Modeling, Analytics & Operational Excellence team is a high-impact innovation team that applies advanced analytics, real-world data, modeling & simulation, and AI / ML to solve critical challenges in clinical development. This team designs and implements predictive models for patient recruitment and retention, optimizes trial feasibility and site selection, assesses novel clinical endpoints, simulates study outcomes to guide protocol design, and develops innovative operational strategies to reduce execution risk and accelerate timelines.

The Clinical Modeling & Analytics Innovation Lead will shape the future of data-driven clinical development by pioneering innovative solutions at the intersection of AI / ML, advanced analytics, modeling and simulation. The position partners closely with colleagues across clinical, biostatistics, real-world data, clinical operations, and digital / IT to improve feasibility assessments, enhance enrollment forecast, deepen data exploration and optimize trial decision-makings. In addition, the Clinical Modeling & Analytics Innovation Lead serves as a strategic partner and innovator, driving adoption of emerging technologies (e.g., generative foundational models, digital twins, and advanced imaging analytics) to transform clinical trial strategy and execution.

Essential Job Responsibilities :

The Clinical Modeling & Analytics Innovation Lead

• Leads cross-functional initiatives applying clinical modeling & simulation, advanced analytics, and AI / ML to trial design, feasibility, and execution optimization.
• Develops advanced simulation and predictive models supporting a variety of critical clinical development tasks, e.g., site feasibility, patient enrollment, endpoint assessment, protocol optimization, operational risk estimation and trial outcome prediction etc.
• Partners with medical, biostatistics, real-world data, and operational teams to embed modeling & analytics insights into protocol development, portfolio planning and decision-making.
• Leads the development of clinical modeling & data strategy and roadmap dedicated to specific business areas, and contribute to portfolio-level clinical modeling strategy and capabilities accelerating and optimizing clinical development.
• Proposes and pilots innovative solutions (e.g., digital twins, trial emulation, hybrid designs, real-time patient targeting) to support trial planning, optimization and execution.
• Represents the organization in external scientific and regulatory forums, and establish thought leadership through publications, presentations, and industry collaborations.
• Mentors junior team members, foster internal quantitative excellence, share best practices and contribute to the culture of innovation, collaboration, and accountability for results .