Senior Manager, Global TaxSummit Therapeutics Sub, Inc. • Menlo Park, CA, United States

Senior Manager, Global Tax

Summit Therapeutics Sub, Inc. • Menlo Park, CA, United States

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Career Opportunities with Summit Therapeutics Sub, Inc.

A great place to work.

Careers At Summit Therapeutics Sub, Inc.

Current job opportunities are posted here as they become available.

Location : Princeton, NJ or Palo Alto, CA onsite

About Summit :

Ivonescimab, also known as SMT112, is a novel, potential first-in-class investigational bispecific antibody combining the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule. Ivonescimab displays unique cooperative binding to each of its intended targets with multifold higher affinity when in the presence of both PD-1 and VEGF.

Summit has begun its clinical development of ivonescimab in non-small cell lung cancer (NSCLC), with three active Phase III trials :

HARMONi is a Phase III clinical trial which intends to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who have progressed after treatment with a 3rd generation EGFR TKI (e.g., osimertinib).
HARMONi-3 is a Phase III clinical trial which is designed to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.
HARMONi-7 is a Phase III clinical trial which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC whose tumors have high PD‑L1 expression.

Ivonescimab is an investigational therapy that is not approved by any regulatory authority in Summit’s license territories, including the United States and Europe. Ivonescimab was approved for marketing authorization in China in May 2024. Ivonescimab was granted Fast Track designation by the U.S. Food & Drug Administration (FDA) for the HARMONi clinical trial setting.

Overview of Role

The Senior Manager, Global Tax is a key role in the company’s corporate tax function, ensuring compliance with all domestic and international tax regulations while developing and implementing effective tax planning strategies. As a sole contributor, the Senior Manager, Global Tax will be working closely with internal stakeholders and external advisors to ensure our company is in compliance with all relevant tax filings, provisions and laws.

Role and Responsibilities

Oversee the U.S. Federal, state, and international tax compliance processes, including income tax filings, estimated tax payments, and audits

Manage the preparation and review of the income tax provision calculations for the quarterly and annual consolidated U.S. GAAP financial statements

Manage the preparation and review of the U.S. and international income tax calculations for payments of estimated tax and filing of the annual tax returns

Collaborate with external tax advisors and internal business teams on the design and implementation of domestic and international tax planning strategies

Review transfer pricing calculations / arrangements on a quarterly / annual basis as needed

Work with accounting to support / review annual statutory tax provision calculations as needed

Manage the Company’s international VAT and other indirect tax exposure and oversee compliance activities

Lead R&D tax credit study

Monitor all tax operations to ensure their timely completion and compliance with all applicable laws and regulations

Support intercompany distribution planning, providing guidance on the U.S. tax implications of global cash movements

Find and implement opportunities for process improvement in company tax procedures.

All other duties as assigned.

Experience, Education and Specialized Knowledge and Skills

Bachelor’s degree is required

Minimum 7 years of tax experience in a Big 4 accounting firm or equivalent corporate tax department experience

Technical proficiency with the preparation of US Federal and state income tax returns and global income tax provisions required

Experience with US international tax computations (GILTI, Sub-F, etc.) and compliance (Forms 5471, 8858, etc.), international tax, and transfer pricing highly desired

Experience with international indirect taxes, including VAT and GST taxes, desired but not required.

Demonstrated ability to operate in a fast-paced environment

The pay range for this role is $168,500 - $198,500 annually. Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus, stock, benefits and / or other applicable variable compensation.

Summit does not accept referrals from employment businesses and / or employment agencies in respect of the vacancies posted on this site. All employment businesses / agencies are required to contact Summit’s Talent Acquisition team at recruiting@smmttx.com to obtain prior written authorization before referring any candidates to Summit.

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Global Tax Manager • Menlo Park, CA, United States