Associate Director, Clinical Operations - PKU South San Francisco, CA

Overview

Associate Director, Clinical Operations – PKU at Maze Therapeutics leads PKU clinical development strategy and trial execution. This role partners with cross-functional teams to manage the PKU Phase 2 study, guiding study design, protocol development, and key milestones. The position offers ownership of the clinical program, collaboration with key opinion leaders, and leadership within Clinical Operations.

Responsibilities

• Clinical Trial Execution & Leadership

Lead or co-lead the Phase 2 PKU clinical trial, aligning execution with the overall clinical development plan from study design and protocol development to completion of milestones (FPI, enrollment, interim analysis, database lock, CSR).

Provide financial oversight across multiple clinical studies, ensuring budget efficiency and alignment with corporate goals

Ensure high-quality clinical trial data and adherence to study protocols, SOPs, ICH GCP; oversee CROs / vendors and monitoring at sites.

Identify and integrate emerging technologies (AI / ML-driven solutions, analytics) to improve trial planning and execution.

Influence program-wide decisions by collaborating with regulatory, data science, CMC, supply chain, and other stakeholders.

Leadership Competencies

As an Associate Director, leadership capabilities include :

Communicate rationale behind decisions and foster open communication with internal and external stakeholders.

Facilitate collaboration across teams and manage conflicts constructively.

Use data-driven judgment, support team problem-solving, and reinforce process compliance and risk mitigation.

Articulate expectations and pursue ongoing development for self and team.

Qualifications

You might be the right fit if you have :

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for renal, cardiovascular, and related metabolic diseases, including obesity. The company uses its Compass platform to map genetic variants to biological pathways and develop targeted therapies. Maze is based in South San Francisco.

Our People and Values

We are a team of professionals committed to transforming patients’ lives through science. We foster an environment that encourages vision, initiative, and talent development, while maintaining a patient-centric focus.

Core Values

Compensation & Benefits

The expected annual salary range for employees located in the San Francisco Bay Area is $185,000 - $226,000. This position is eligible for an annual bonus. Maze conducts compensation benchmarking. Starting salary depends on experience, skills, and location. Benefits include medical, dental, vision, mental health offerings, equity, 401(k) with employer match, and generous holiday and PTO policies.

Other Information

Maze supports a hybrid work environment. #LI-Hybrid

#J-18808-Ljbffr