Scientific Leader, Molecular Design

Molecular Design Team Position

We are seeking a highly motivated individual to join our Molecular Design team in Molecular Modalities Discovery. At GSK, we aim to efficiently accelerate the discovery and development of transformational medicines through the integration of advanced computational methods, predictive in silico models, and expert analyses. By applying these computational strategies, we will shape the company's future by working across all of GSK's Pharma R&D teams to deliver a strategy that informs the most efficient way to deliver novel therapeutic modalities through computational design and achieve GSK's therapeutic requirements for a clinically differentiable medicine. The successful applicant will collaborate with preclinical research and development business partners to impact the pipeline from target identification, modality selection, and molecule design to ultimately identify clinical candidate therapeutics that will greatly improve and impact the lives of the patients we serve.

Key Responsibilities :

• Collaborate with experimental groups to drive compound design and improve models using structure-based drug design, QSAR modeling, QM methods, and methods of computationally modeling macromolecular systems.
• Predict and evaluate targets for their probability of success to be drugged across various modalities including small molecules, oligonucleotides, protein degraders and antibody drug conjugates.
• Work with biology team members to assimilate data from experiments, optimize those experiments, and integrate that data into compound design.
• De novo design and multi-objective optimization of tool compounds and target specific medicines.
• Partner with multidisciplinary computational groups to develop and embed computational methods in visualization packages to enable experimental multi-variate analysis and data-driven decision-making.
• Collaborate with external groups to further develop computational methods to enhance our internal compound design and synthesis.
• Stay up-to-date with the latest developments in computational chemistry as it relates to DNA / RNA therapeutics, small molecules, PROTACs and other modalities.

Why You?

Basic Qualifications :

Preferred Qualifications :

Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose to unite science, technology and talent to get ahead of disease together so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns as an organization where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory / immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged, and challenged to be the best they can be. A place where they can be themselves feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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