Medical Director

Job Description

Job Description

Salary : THE COMPANY

89bio is a clinical-stage biopharmaceutical company dedicated to the development of best-

in-class therapies for patients with liver and cardiometabolic diseases who lack optimal

treatment options. The company is focused on rapidly advancing its lead candidate,

pegozafermin, through Phase 3 clinical development for the treatment of metabolic

dysfunction-associated steatohepatitis (MASH) and severe hypertriglyceridemia (SHTG).

Pegozafermin is a specifically engineered, potentially best-in-class fibroblast growth factor

21 (FGF21) analog with unique glycoPEGylated technology that optimizes biological activity

through an extended half-life. The company is headquartered in San Francisco.

SPECIAL ADVISORY

The FTC has an advisory out on the domain 89biocareers.com if you are contacted by any

group using a similar, but not our exact domain 89bio.com, please Report any Scams.

THE ROLE

Reporting to the Executive Medical Director the Medical Director will be primarily responsible

for providing medical and scientific expertise to support our Phase 3 clinical MASH program

primarily focused on cirrhosis. The Medical Director will serve as a key clinical leader working

cross-functionally with Clinical Operations, Regulatory Affairs, Pharmacovigilance,

Biometrics, and external partners to ensure the integrity, safety, and success of our late-stage

trials.

THE RESPONSIBILITIES

• Serve as one of the Medical Monitors for ongoing Phase 3 trials, overseeing medical

oversight, safety signal detection, and protocol compliance.

conduct documentation (e.g., IBs, ICFs, SAPs).

support for database locks, interim analyses, and regulatory submissions.

events and serious adverse events, ensuring timely escalation and communication.

functional program team discussions.

and responses to health authorities.

to support trial execution and data integrity.

MASH, liver fibrosis, and metabolic diseases.

operations, regulatory, biometrics, safety and other functions as needed throughout the

organization

30%.

THE QUALIFICATIONS

Hepatology, or Internal Medicine with a focus on metabolic diseases preferred.

monitoring, ideally with late-phase experience in liver / metabolic diseases (MASH and

cirrhosis specifically).

medical oversight, and regulatory engagement.

with CROs and external stakeholders.

development processes.

clinical data into strategic insights.

SALARY & LEVEL

89bio considers a range of factors when determining salary and level. These considerations

mean actual salary and level may vary. The expected salary range for this position based on

the primary location for this position in Northern California is $263,000 $315,000.

89bios role / level assessment approach involves assessing candidates during the interview

process before confirming the level / title designation. The level assessment is considered on a

case-by-case basis. Offer and level is based on factors such as : education, experience,

qualifications, geographic location, transferable skills, licenses / certifications and other job-

related factors permitted by law.

THE PERKS

CONDITIONS OF EMPLOYMENT

All qualified applicants will receive consideration for employment without regard to race, sex, color,

religion, sexual orientation, gender identity, national origin, protected veteran status, or based on

disability.

89bio is committed to the full inclusion of all qualified individuals. As part of this commitment, 89bio will

ensure that persons with disabilities are provided reasonable accommodations for the hiring process,

and / or to perform essential job functions where the requested accommodation does not impose an undue

hardship.

Notice to Recruiters : To protect the interest of all parties, 89bio does not accept unsolicited resumes and

we ask that employees, hiring managers and executives not be contacted directly. All recruitment is

managed through the 89bio Talent Acquisition Team.