Senior Scientist - Bioprocess Development

The Senior Scientist / Principal Scientist in Bacterial Bioprocess Development plays an essential role in the Zoetis vaccine and biopharmaceutical strategies for veterinary medicine. The successful applicant will work as a Subject Matter Expert (SME) in the development of fermentation and bioreactor protocols in support of global product development and GMP (Good Manufacturing Practice) manufacture of biological veterinary products. The incumbent is expected to work hands-on at the bench while also providing strong technical and strategic leadership to project teams. The scientist is expected to work with a high degree of autonomy in the discipline and work on project teams in collaboration and partnership with colleagues in downstream process development, formulation development, and bioanalytical sciences. They will serve as a key technical resource within the line, may lead functional and cross-functional teams, and will have advanced knowledge of related bioprocessing unit operations such as cell line development, seed banking, and protein purification techniques. The position is based in Lincoln (Nebraska, USA) with frequent interactions with colleagues and external partners located around the globe.

Responsibilities :

The major duties will include but are not limited to :

• Independently apply an advanced knowledge of biological manufacturing science in the design and execution of bioreactor experiments to identify and validate critical parameters that affect upstream and downstream bioprocess performance across multiple scales. The parameters to be investigated include reactor engineering and configuration, medium formulation, and fed-batch strategies.
• Systematically identify and optimize the key parameters that affect bioreactor performance through the application of statistical models for experimental design and analysis.
• Perform and support antigen production, purification and / or concentration processes to support mono- and multivalent vaccine development.
• Partner in collaboration with colleagues in pilot and manufacturing scale operations to devise scale-up strategies for fermentation processes. Provide technical leadership using key knowledge of engineering first principles and computational flow dynamic (CFD) modelling in scale up programs based on risk assessment of critical parameters and their impact on product quality attributes.
• Perform set-up, operation and validation of equipment used to generate experimental data. Ensure the maintenance and performance of the equipment is kept in good operational status. Coordinate with internal and external sources to evaluate new technologies or troubleshoot issues with existing equipment.
• Serve as a technical resource to project teams by providing the essential expertise in biological manufacturing science required for successful project delivery. This includes a willingness to share experimental findings with team members, peers, and management.
• Independently drive innovation and continuous improvement by conducting laboratory experiments to evaluate new bioprocess technologies.
• Maintain electronic laboratory notebooks and records in accord with scientific protocol and applicable Standard Operating Procedures. Document experimental findings through periodic authorship of progress reports that will be included in dossiers for product registration and technology transfer.

Basic Qualifications

Possess a relevant degree in science or engineering, such as Biochemistry, Molecular Biology, Cell Biology, Biotechnology, Chemical / Biochemical Engineering, or Biomedical Engineering.

For Senior Scientist Level :

For Principal Scientist Level :

Preferred Qualifications :

Full time

Regular

Colleague

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About Zoetis

At Zoetis , our purpose is to nurture the world and humankind by advancing care for animals. As a Fortune 500 company and the world leader in animal health, we discover, develop, manufacture and commercialize vaccines, medicines, diagnostics and other technologies for companion animals and livestock. We know our people drive our success. Our award-winning culture, built around our Core Beliefs, focuses on our colleagues' careers, connection and support. We offer competitive healthcare and retirement savings benefits, along with an array of benefits, policies and programs to support employee well-being in every sense, from health and financial wellness to family and lifestyle resources.

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