Senior Associate Scientist, Biology

This role is considered On-Site.

Overview

We are seeking a talented candidate to fill an Senior Associate Scientist position within Alnylam's Research department.

This position is an opportunity to potentially see one's work progress from the bench to the clinic and positively impact patients' lives with metabolic diseases.

The successful candidate will support early development of potential therapeutic programs as part of a multidisciplinary team and be involved in the discovery of RNAi compounds for a indications related to obesity, diabetes and other rare metabolic conditions.

The successful candidate will have background in biological sciences and be technically skilled in basic molecular biology techniques and work with rodent species.

Responsibilities will include designing, developing, and executing studies in rodent obesity models using small interfering RNAs (siRNAs) and conducting the associated in vitro molecular-based assays such as qPCR, western blots, and ELISAs.

Passion for science, a desire to learn new techniques, as well as experience and willingness to work with rodents are a must!

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Contribute to study design and execution of studies to characterize molecules for RNAi therapeutic programs, including rodent metabolic disease models
• Develop and conduct assays such as qPCR, western blot, and ELISA, that support in vivo studies
• Perform in vitro and cell-based assays to characterize drug activity
• Perform in vivo procedures in rodents, including administration of therapeutics via established methodologies
• Analyze and interpret the data
• Prepare clearly articulated experimental reports and data presentations
• Prepare of SOPs / protocols
• Present data to groups within and outside of Research

Qualifications

Minimum B.S. degree in a life sciences-related discipline such as Molecular Biology, Cell Biology, or Genetics with 4+ years of experience in laboratory research or a M.

S. degree with 2+ years of experience in laboratory research

• Proficiency in RNA / DNA / protein analysis techniques, including ELISA, western blotting and qPCR
• Cell / tissue culture experience
• Basic rodent in vivo skills (animal handling, subcutaneous / intravenous dosing, blood collection, and necropsy / dissection expertise) is highly desired
• Experience setting running obese rodent disease models is highly desired
• Ability to perform and troubleshoot assays independently or with limited direction of supervisor(s) / project leader(s)
• Demonstrate keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously and independently analyze results, propose future directions and generate clear reports
• Must be flexible, open to new tasks and challenges and able to work on tight deadlines
• Proven ability to work in a team environment and across functional areas
• Cover letter encouraged

About Alnylam : Alnylam Pharmaceuticals (Nasdaq : ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases.

Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease.

Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture : Our people-first culture is guided by our core values : fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make.

Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential.

By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.