Scientist/Senior Scientist, Analytical Research and Development (Biophysics)

The Company

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Verve Therapeutics is a biotechnology company created with a singular focus : to protect the world from heart disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, the company aims to develop transformative, once-and-done therapies for coronary heart disease.

Verve’s gene editing medicines are designed to safely edit the genome of adults and mimic naturally occurring gene variants to permanently lower LDL cholesterol and triglyceride levels.

The company is advancing a pipeline of precision genetic medicines, led by VERVE-101, which is being developed initially for heterozygous familial hypercholesterolemia, a potentially fatal genetic heart disease.

In 2022, Verve was selected as a Top Places to Work by The Boston Globe. Verve is headquartered in Boston, Massachusetts.

The Position

Verve is seeking a Scientist / Sr Scientist within the Analytical Research and Development team, to develop and implement biophysical and separation methods and technologies to characterize mRNA, gRNA and LNP-encapsulated gRNA and mRNA.

This individual will be interfacing with a cross-functional team to design, develop and support phase-appropriate analytical methods to enable Verve’s growing gene editing pipeline.

The position will be part of an integrated R&D team that aims to advance preclinical gene editing candidates into the clinic and work closely with discovery and process development groups.

Job Responsibilities

• Develop, optimize, and execute analytical methods intended for a variety of purposes, including product characterization, high throughput analysis, and characterization of complex raw materials.
• Review, interpret, and present data within the analytical team and cross-functionally.
• Provide technical oversight for troubleshooting and phase-appropriate qualification of analytical assays for the analysis of gRNA, mRNA and LNP.
• Assist in authoring, reviewing, revising technical source documents to support phase appropriate comparability.
• The successful candidate may also provide technical oversights to guide analytical / QC investigations, as needed.
• Train and mentor junior team members.
• Other duties as assigned.

Qualifications

• PhD in Chemistry, Biophysics, Biochemistry, Bioengineering, or related life sciences field with strong scientific background.
• M.S. in Chemistry, Biophysics, Biochemistry, Bioengineering, or related life sciences field with strong scientific background with 4+ years’ relevant experience.
• Bachelor’s degree with 7+ years of related industry experience.
• Hands on experience developing and troubleshooting analytical methods applied to complex and heterogenous systems (e.g.

HPLC / UPLC, capillary electrophoresis, cryoTEM, NMR, MALS, DLS, NTA, etc.).

• Previous experience developing methods for gRNA, mRNA, LNP.
• Advanced competence in operating and troubleshooting HPLC / UPLC instrumentation.
• Conceptual understanding of solid phase oligonucleotide synthesis and purification strategies.
• Must have hands-on experience analyzing DNA / RNA by a variety of techniques (e.g. IP-RP, IEX, LC-fluor, multi-modal LC, etc.).
• Advanced understanding of lipid nanoparticle delivery, production and purification.
• Familiarity with applicable ICH regulations and multi-compendial guidelines related to method validations.
• Excellent organization and planning skills.
• Strong interpersonal skills.
• Flexible to accommodate changing priorities and deadlines.

EEO Statement

Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

If you have a disability or special need that requires accommodation, please let us know.

Recruitment & Staffing Agencies

Verve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location;

Verve Therapeutics is not responsible for any fees related to unsolicited resumes.

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