Principal Scientist Medicinal Chemistry

Introduction to role :

Are you ready to lead small molecule projects as the Medicinal Chemistry project leader? We're looking for a Principal Scientist to provide scientific leadership of PhD and BS / MS level internal medicinal chemistry and CRO resources.

You'll have the opportunity to provide wider project and strategic feedback to the rapidly growing small molecule portfolio!

Accountabilities :

Lead small molecule multidisciplinary projects with internal and external medicinal chemistry resources. You'll be accountable for design strategy and deliverables in lead optimization and lead generation phases.

You'll work closely with biology project leads, DMPK project leads, and other scientists in small molecule research to deliver development candidates for various targets.

You'll also serve as a subject matter expert in chemistry with internal and external partners and provide recommendations regarding new targets and emerging external opportunities as needed.

Essential Skills / Experience :

• Ph.D. in synthetic organic or medicinal chemistry with 10 plus years of drug discovery experience
• Specific experience leading projects from inception to development candidate nomination in a pharmaceutical and / or biotechnology setting
• Experience scientifically leading internal and external chemistry resources as a project leader without line manager authority
• Excellent communication, leadership, collaboration and interpersonal skills
• Strong track record of innovation demonstrated by patent inventorship, peer-reviewed publications, and conference presentations
• Experience in hit identification techniques and progressing compounds from hit identification to development candidates
• Extensive CRO management experience
• Experience in structure-based drug design with strong design hypothesis

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines.

In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work five days per week on-site in the office.

But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility.

Join us in our unique and ambitious world.

At AstraZeneca, we bring patients closer. Everything we do is led by their lived experience, driving what we do and how we do it.

We know our patients by name, we meet their families and their careers. Curious, co-creative, attentive and close to each one, razor focused on their needs so we can tackle the toughest challenges for them.

Joining Alexion, AstraZeneca, Rare Disease means embracing an opportunity where work isn’t ordinary, in a company where 'Here it means more' is more than a statement, it’s an ethos.

We are a beacon in the global Biopharmaceutical landscape. Our closeness to patients brings us closer to our work and closer to each other.

Combined with our brave, pioneering spirit we are truly unique in R&D and healthcare.

Ready to make a difference? Apply today!

Date Posted

28-Aug-2024

Closing Date

30-Dec-2024Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness.

The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law.

Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding an accommodation, please contact Alexion participates in E-Verify.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.