Research Associate Scientist, Investigative Toxicology

OBJECTIVES :

Do you have the following skills, experience and drive to succeed in this role Find out below.

The Global Investigative Toxicology team is a cross-functional team of scientists that aim to detect and de-risk toxicity in Takeda’s portfolio to help make medicines safer and more effective.

We are looking for a Research Associate Scientist to support these efforts across small molecule, biologics and cell therapy platforms.

The Research Associate Scientist will contribute ideas and deliver decision-making data to inform design and prioritization of drug candidates.

• Work as part of a global team of safety assessment scientists to detect and de-risk toxicities associated with various modalities.
• Design and implement early safety assessment screening strategies to enable the progression of optimized therapeutic candidates.
• Conduct cell-based in vitro assays to characterize immune-mediated toxicities for medicines in discovery & development.
• Develop novel in vitro model systems to assess safety risks associated with new therapeutic designs.

ACCOUNTABILITIES :

• Develop, design, execute, and interpret in vitro cell-based assays to characterize diverse mechanisms of drug candidates.
• Maintain cultures of immortalized tumor cell lines, primary cell types of various origin (lung, liver, kidney, intestine, pancreas, etc.

and primary immune cells (T cells, B cells, NK cells, etc.).

• Perform fit-for-purpose ex vivo analyses to assess phenotypic and functional correlates of toxicity.
• Prepare experimental protocols, analyze experimental data, and present study results in team and department meetings.
• Contribute ideas to drive innovation within investigative toxicology and with key collaborators (e.g. pharmacology, DMPK, bioinformatics).
• Document experimental methods and findings in electronic laboratory notebook.

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS :

• MS. with 3+ years or BS with 5+ years of experience in immunology, biology, biochemistry, pharmacology, or a related discipline.
• Expert with standard aseptic cell culture technique, including experience culturing various tumor cell lines and primary cells.
• Broad experience with cell-based functional assays, including cytotoxicity, cytokine release, and proliferation assays.

Experience with flow cytometry is highly preferred.

• Basic experience with molecular biology techniques including RNA / DNA extraction, qPCR, western blot.
• Experience working in a matrixed team environment at a pharmaceutical company and / or CRO.
• Broad scientific knowledge in immunology and pharmacology.
• Self-motivated with strong time management and organizational skills.
• Ability to balance multiple projects and flexible with changing priorities.
• Highly collaborative with demonstrated ability to work in a matrixed team environment.
• Excellent oral and written communication skills.

LICENSES / CERTIFICATIONS :

PHYSICAL DEMANDS :

Routine demands of an office-based environment.

TRAVEL REQUIREMENTS :

• Ability to travel domestically and internationally,
1 day ago