Associate Scientist II, Downstream Pilot Plant, Protein Process Development & Manufacturing
Associate Scientist II, Downstream Pilot Plant, Protein Process Development & Manufacturing
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Scientific San Carlos, California Direct Hire Feb 12, 2024
The company is looking for an energetic and talented individual to manage and operate the downstream pilot-scale operations in our San Carlos pilot plant facility within the protein process development and manufacturing group.
This is an opportunity to learn scale-up operations with exposure to supply chains, CMOs, and development work. By scaling up production of proteins for the company’s clinical pipeline, the pilot plant will not only generate needed materials for development use but also generate highly valuable data on process performance, consistency, scale-up, and reuse.
The successful candidate will have the following skills and qualities :
- An exceptional team member that fosters a highly collaborative work environment.
- A confident individual who speaks up, is open to input, and remains focused on achieving the best results to achieve company goals.
- A diligent scientist / engineer who enjoys process execution and scale-up.
- The ability to clearly present data, trend longitudinal data, draw conclusions, and communicate salient points concisely.
- A strong sense of ownership and accountability; commitment to the company’s mission.
Essential Functions :
- Operate and maintain the Downstream pilot plant production line in the company’s San Carlos facility.
- Preparation of buffers, execution of chromatography, tangential flow filtration, and normal flow filtration systems.
- Support for Upstream pilot plant operations.
- Develop and optimize process records that clearly instruct and efficiently facilitate the capture of data.
- Schedule and manage logistics of routine pilot production of proteins to support the company’s pipeline.
- Support scale-up activities for processes as part of technology transfer to CMOs.
- Contribute to process development for protein processes as time allows.
- Run in-process tests and product quality assays to support pilot production.
- Generate written summaries of production runs.
- Packing columns from loose resin.
- Buffer preparation up to 200L.
Requirements :
- BS in Chemical Engineering, Biochemistry, or a related discipline, with 2+ years of industry experience.
- Strong protein purification knowledge and experience, including familiarity with AKTA Pilot (or Avant) chromatography systems and UNICORN software.
- Proficiency running analytical methods a plus; such methods may include SDS-PAGE, Endosafe, UV spectroscopy, and HPLC.
- Experience operating tangential flow filtration systems; single-pass TFF is a plus.
- Experience with Benchling ELN is a plus.
- Strong interpersonal skills, with excellent written and verbal communication skills.
- All employees require vaccination against COVID-19.
Reports to : Staff Scientist, Protein Process Development and Manufacturing
Location : San Carlos, CA
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