Associate Scientist/Scientist/Sr. Scientist - Upstream Process Development

About Enlaza Therapeutics

Enlaza Therapeutics is a biotech company developing an innovative synthetic biology platform to create a disruptive new class of biologic therapeutics.

We are dedicated to the development of these novel therapies to help patients suffering from cancer and other serious diseases.

Role Description :

As a key member of the Upstream Process Development Team, the candidate will play a crucial role in designing and optimizing bioreactor processes to produce protein biologics from E.

coli . The role requires a balance of hands-on lab work and mentoring junior team members. The successful candidate will possess deep technical expertise in upstream process development and a collaborative spirit to work effectively across internal teams.

Responsibilities :

• Design, plan, and execute on key experiments to further Upstream Process Development of the proprietary Enlaza protein production platform, including assisting in the setup and breakdown of bioreactors.
• Enhance manufacturing technologies, capabilities, and processes including, optimizing media, physical conditions, feed profiles, and scale-up.
• Mentor and guide junior team members in experimental protocols, troubleshooting experimental issues, and equipment handling.
• Generate, manage, evaluate, and maintain critical data with high organizational standards, including the initial vetting of bioreactor run integrity.
• Improve ELN templates and develop tools for more efficient bioreactor data collection and presentation.
• Author comprehensive technical reports, tech transfer documents, and SOP’s
• Prepare and deliver scientific presentations as required.
• Collaborate closely with cross-functional scientists to meet project goals and produce required proteins.
• Ensure the maintenance of UPD group inventory, including cell banks, stock solutions, and materials; oversee the troubleshooting of operational processes and equipment issues.

Qualifications / Requirements :

• BS in Biochemical Engineering, Biological Sciences, or a related field with 5+ years relevant industry experience, or MS with 2+ years relevant industry experience.
• Extensive experience with manufacturing cell culture process development, primarily with microbial systems.
• Proven hands-on experience with small-scale bioreactor set-up and operations, along with flasks.
• Strong laboratory skills, including molecular biology techniques (e.g., western blots)
• Demonstrated ability to write detailed technical documents such as tech transfer documents, SOPs, and progress reports.

Preferred

• Direct experience with E. coli upstream process development for biologics.
• Proficiency in programming reactor control systems, e.g. DASware and Applikon Lucculus.
• Experience with Benchling, particularly with Benchling insights or API.
• Experience with advanced data analysis tools and software, such as Python, or JMP.
• Familiarity with cGMP and tech transfer to CDMOs
• Knowledge of regulatory requirements and quality control processes for biologics production.
• Experience in project management or leading projects in a biotech or pharmaceutical setting.
• Strong communication and interpersonal skills for effective cross-functional collaboration.
• Demonstrated problem-solving skills and innovative thinking.

Compensation :

In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.