Vice President Supply Chain

Position Summary

Upstream Bio is seeking an experienced and strategic Vice President, Supply Chain to lead the development and execution of our global clinical and commercial supply strategies. This role will oversee supply chain operations across all programs from current phase 2 programs through commercialization. As a key member of the Technical Operations leadership team reporting into the Chief Technical Officer, the VP will ensure the timely, compliant, and cost-effective supply of clinical trial materials and commercial product, while building a fit-for-purpose organization capable of scaling with the company’s pipeline and market ambitions.

The ideal candidate brings a track record of successfully managing complex global clinical trial supply chains, navigating regulatory requirements, and launching commercial products in the biotech or pharmaceutical industry, including early access program program considerations. This leader will bring strategic foresight, strong cross-functional collaboration skills to align stakeholders, and operational discipline to deliver results in a dynamic, fast-paced environment.

Key Responsibilities

Strategy & Leadership

• Establish the clinical and commercial supply chain strategies, creating an integrated supply chain to successfully launch Upstream Bio’s first biologic combination products.
• Lead and drive cross-functional alignment and integration across Clinical Operations, Regulatory, Quality, Technical Operations, Finance, and Commercial functions.
• Define standards and approach for business process management across the supply chain and drive excellence in end-to-end operations through identification and management of supply chain key performance indicators (KPIs).
• Establish and lead Clinical Demand & Operations Planning (CD&OP) and Sales & Operations Planning (S&OP) processes to align cross-functional teams and drive business plans to improve supply planning, increase service levels, optimize inventory, and achieve the company’s financial targets.
• Build and scale internal capabilities and infrastructure to support long-term growth and operational excellence, including supply chain risk mitigation.
• Optimize existing integrated global supply chain strategy for clinical programs.
• Anticipate and plan for future needs including Phase 3 trial readiness and commercial launch.
• Provide leadership and direction to the supply chain function, including supply planning and forecasting, logistics, distribution and vendor management.
• Build, mentor, and scale a high-performing global supply chain team.

Clinical and Commercial Supply Operations

Vendor and Partner Management

Compliance and Regulatory Support

Qualifications

About Upstream Bio

Upstream Bio is a public company based in Waltham, MA. We are developing verekitug, the only known antagonist currently in development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP). We have advanced this highly potent monoclonal antibody into separate Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) and plan to initiate development in chronic obstructive pulmonary disease (COPD). Our experienced team is committed to maximizing verekitug’s unique attributes to address the substantial unmet needs for patients underserved by today’s standard of care. Learn more about us at upstreambio.com.

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