Staff Research Associate I

Aug 08, 2024

The following information aims to provide potential candidates with a better understanding of the requirements for this role.

Staff Research Associate I

NeuSrg-General

Full Time

78489BR

Job Summary

The Liu Laboratory within the UCSF Departments of Radiation Oncology and Neurological Surgery and the Director of the UCSF Brain Tumor Center are recruiting a highly motivated candidate with prior laboratory experience to fill a Staff Research Associate position.

The Brain Tumor Center at UCSF focuses on developing new treatments for patients with malignancies of the central nervous system by :

• Studying the mechanisms through which brain tumors develop and become resistant to treatments.
• Identifying novel therapeutic targets using molecular biology, CRISPR genome and epigenome editing, biochemistry, mouse genetics, bioinformatics, pharmacology, and multidisciplinary collaborations.

We work collaboratively with basic scientists, computational biologists, and physician-scientists at the UCSF Helen Diller Cancer Center and broadly throughout the UCSF Campuses.

Please refer to this link for an overview of research efforts.

Under direct supervision and guidance, the Staff Research Associate will play an instrumental role in developing and deploying genetic and epigenetic editing technologies for treating malignant gliomas, working side-by-side with physician-scientist investigator Dr.

John Liu (MD / PhD Assistant Professor) and under supervision of Dr. Mitchel Berger, Director of the UCSF Brain Tumor Center.

This project specifically involves close collaboration across the labs of the UCSF Brain Tumor Center as well as the UCSF Preclinical Therapeutics Core.

The employee will learn and utilize a variety of research techniques and have the opportunity to be a co-author on publications as well as present at international conferences.

Responsibilities

Under direct supervision and guidance, the job responsibilities and opportunities include but are not limited to :

• Molecular biology including molecular cloning, PCR, DNA / RNA / Protein analysis, DNA methylation epigenetic analysis including bisulfite sequencing.
• Culturing human and mouse cancer cell lines, primary brain tumor cultures, and organoids.
• Flow cytometry, immunofluorescence, and confocal microscopy analysis.
• Performing gene knockdown and epigenetic editing using engineered CRISPR / Cas9 technologies, including genome-wide CRISPR screens.
• Assisting with mouse colony management, including breeding, weaning, tagging, and PCR genotyping.
• Assisting with intracranial xenograft studies and pharmacologic experiments in mice.
• Dissection and dissociation of tumor xenografts for single cell RNA-seq and multi-omics analysis.
• Assisting with lab maintenance duties including acquisition of materials and documentation.

Prior familiarity with these techniques is a plus but not required, and a willingness to learn new techniques is expected.

In addition, the successful applicant will receive direct mentorship to ensure that specific laboratory responsibilities are tailored and directed toward future career objectives, such as the pursuit of a MD, biomedical PhD, or MD / PhD.

Required Qualifications

BA / BS in a related science and knowledge of, or experience with, the basic techniques or methods required by the position;

and / or an equivalent combination of education and experience.

• Strong degree of self-motivation, eagerness to learn and think critically, and enthusiasm for science and / or medicine.
• Attention to detail and problem-solving ability.
• Demonstrated reliability and integrity.
• Strong organizational, communication, and documentation skills.
• Initiative to work well as part of a team and also independently.

Preferred Qualifications

• Basic knowledge and understanding of cancer biology.
• Effective use of laboratory instruments and their maintenance; knowledge of biomedical and biotechnological techniques and methodologies.
• Working knowledge in tissue culture and basic molecular / cell biology.
• Knowledge and experience with CRISPR / Cas9 techniques.

About UCSF

The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.

It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences.

The University of California San Francisco is an Equal Opportunity / Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.

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