Principal Scientist I, Precision Medicine Translational Research Immunology

Job Description

We are seeking a highly motivated and creative Scientist with a scientific background in immunology or immuno-oncology to join Precision Medicine Translational Research Immunology Group as Principal Scientist at AbbVie.

The candidate will provide leadership in clinical biomarker strategy and assay development in inflammatory / autoimmune disease areas, including Dermatology, Gastroenterology, Rheumatology and Fibrosis for AbbVie’s drug development programs from late discovery to clinical trials.

The successful candidate will be part of a growing translational research group working with cross-disciplinary teams both internally and externally.

Key Responsibilities :

• Lead biomarker strategies through cross-functional teams in a matrix environment to identify gaps and develop fit-for-purpose clinical TE / PD biomarker, predictive and exploratory biomarker assays to support human dose projection and establish early signs of efficacy in clinical trials and patient selection strategies.
• Collaborate with Data Science team and Precision Medicine lead to analyze internal and external omics data, understand heterogeneity of diseases, identify disease endotypes, support disease strategy and generate patient selection and combination hypotheses for further testing with preclinical studies.
• Develop preclinical patient derived disease models, design studies with appropriate controls and endpoints to understand drug target mechanisms for PD biomarker development and evaluate biomarker hypotheses and combination strategies.
• Serve as a subject matter expertise in analytical methodologies / technologies for translational research including single cell and spatial omics, proteomics, methylomics, metabolomics, genomics, NGS, MSD, ELISA, Luminex, flow cytometry, ex vivo primary cell culture and organoid-immune cell culture.
• Manage external CROs and academic collaborations including study proposal, budget, timeline, and data review.
• Manage and coach a team of translational scientists, ensuring the successful execution of translational research plans across multiple projects.
• Keep abreast of latest research & development in inflammatory and immune diseases through critically reviewing literature, attending conferences, and seeking advice from KOLs.

Qualifications

Qualifications :

Major or advanced degree in Immunology, cell & molecular biology, pharmacology, pathology, bioinformatics or other relevant biological sciences.

B.S. & typically 14+ years, M.S. & typically 12+ years, Ph.D., or equivalent & typically 8+ years of relevant industrial biotechnology experience.

• Experience in leading translational medicine in Rheumatological diseases (RA, SLE, SSc) is a plus.
• Expertise in a broad range of translational technologies, data analytics and computational tools.
• Proficient in multi-parameter flow cytometry, including spectral flow cytometry and analytical software (e.g., BD FACSDiva, Flowjo, OMIQ) to analyze different immune cell types and cell states from mice, human and cynomolgus monkey.
• Experienced in designing and conducting single cell omics, spatial omics, genomic-based assays and developing analytical workflow to generate or validate biomarker hypotheses.
• Knowledgeable with integrative analysis of multi-dimensional datasets using bioinformatics tools and methods (e.g., R, Python, SQL, AI / ML, HPC and cloud environments)
• Strong project leadership and organizational skills to prioritize tasks and allocate resources to meet projects’ goals in a tight timeline.
• Experienced in managing CROs and collaborators, facilitating meetings, and working independently and collaboratively with multi-functional teams in a dynamic and fast paced environment.
• Demonstrated ability to supervise and coach direct reports.
• Excellent communication, presentation, organizational and people management skills
• Strong track-record of scientific publications from peer reviewed journals and presentations in major conferences

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law :

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position.

Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range.

This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical / dental / vision insurance and 401(k) to eligible employees.

This job is eligible to participate in our short-term incentive programs.

This job is eligible to participate in our long-term incentive programs

Note : No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.

It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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