Principal Scientist, Translational Sciences

Principal Scientist, Translational Sciences

Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases.

We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible.

Check out the role overview below If you are confident you have got the right skills and experience, apply today.

Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California.

At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work.

What Matters to Us

Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative.

We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.

Arcellx Core Values

• Character : Committed to always doing what’s right.
• Audacity : Willing to challenge convention and share candid feedback with others.
• Determination : Curious and self-motivated. Always looking to improve and learn.
• Collaboration : "No job is too small" mentality. Humble and willing to help others.
• Originality : Will bring your unique perspective to the table and respect a diverse set of views and backgrounds.

How You’ll Make a Difference

As a Principal Scientist on the Translational team, you’ll join a dynamic group responsible for driving the development and execution of translational strategy as projects move from discovery to early clinical development.

You’ll work with cross-functional project teams and will be accountable for defining decision-enabling biomarker strategies and integrating biomarker activities for projects in development with a primary focus on hematologic malignancy programs.

The Fine Print What You’ll Do

• Lead implementation of clinical biomarker strategy to enable target engagement characterization, PK / PD indication of biologic activity and assessment of patient response.
• Serve as a key contributor to integrate, influence, and execute on translational / biomarker plans.
• Communicate translational updates and conduct strategic discussions for key programs with diverse audiences, including senior management.
• Understand key cancer pathway interactions and feedback mechanisms in clinical samples to inform ongoing clinical trials.
• Define novel mechanisms of resistance by studying samples at relapse.
• Contribute relevant scientific expertise, strategy, and experimentally-derived insights as a member of multidisciplinary project teams working to drive the preclinical to clinical translation of pipeline assets.
• Plan, design, and execute IND-enabling pharmacology, pharmacokinetic and toxicology studies by applying knowledge of disease-associated pathways, preclinical models, and drug development.
• Contribute to the preparation of IND applications and other regulatory documents, as appropriate, leveraging up-to-date knowledge of FDA cellular therapy guidance.
• Establish and cultivate relationships with external CRO collaborators for basic and translational research.
• Maintain a current and comprehensive understanding of disease biology, treatment paradigm, and competitive landscape for key programs.

Skills and Experience We Look For

• PhD, MD or MD / PhD degree in a relevant scientific field (e.g., cancer biology, immunology, hematology) with 3+ years of experience in a formalized Translational Science / Medicine role within a large pharma / biotech company is required.
• Understanding of early or late-stage drug and translational development process, including clinical trial experience in industry or academia.
• In-depth understanding of myeloid disease biology (e.g., AML, MDS), knowledge of clinical landscape, evolving therapy, and competitive scenarios.
• Demonstrated record of research accomplishment as evidenced by publications or major contributions to drug development milestones.
• Highly developed problem solving and risk management abilities.
• Strategic thinker with proven leadership skills and / or prior project team leadership roles.
• Proficiency in distilling complex issues and clearly articulating viable paths forward.

Rewards at Arcellx

Our people are our greatest asset, and supporting their well-being is an essential part of delivering on our mission and impacting the lives of patients.

Putting this belief into practice means offering strong compensation and benefits.

In addition to a competitive base salary, our compensation package includes an annual bonus based on company goals and an equity (RSU) grant.

We do offer relocation assistance for roles if required.

Our market-leading benefits package includes : 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more.

Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to www.arcellx.com .

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