SR. MANAGER, QUANTITATIVE CLINICAL PHARMACOLOGY

Why Sarepta? Why Now?

The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development in gene therapy, RNA and gene editing.

In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.

We're looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.

What Sarepta Offers

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives.

We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity.

We are committed to offering a range of benefits and work-life resources designed to support people in the following areas :

• Physical and Emotional Wellness
• Financial Wellness
• Support for Caregivers

For a full list of our comprehensive benefits, see our website : https : / / www.sarepta.com / join-us

The Importance of the Role

The Sr. Manager, Quantitative Clinical Pharmacology is responsible for providing translational, clinical pharmacology and pharmacometric deliverables for development assets from pre-IND to Phase III.

This incumbent will apply quantitative modeling methodologies inclusive of population PK, PKPD, quantitative system pharmacology (QSP), disease progression modeling using multivariate statistical and empirical approaches, as well as AI / ML based algorithms to integrate, analyze and interpret diverse data sources (e.

g., pharmacokinetics, pharmacodynamics including biomarker & imaging, electronic health records).

The Opportunity to Make a Difference

• Perform advanced pharmacometrics, QSP and disease progression analyses and activities within assigned programs to yield high value population PK, PK / PD, QSP and disease progression modeling support for critical decision making
• With guidance, implement novel data analytics and solutions for data visualizations, automation of analytics workflows for nonclinical and clinical data
• With guidance, collaborate with stakeholders to co-develop data workflow and dashboards that facilitate centralized database and access, model utilization and output interpretation
• Influence internal and external environment through publication and presentations at key scientific conferences and consortia

More about You

• PhD degree in pharmaceutical sciences, pharmacometrics, biomedical engineering, statistics, applied mathematics, or a related field with a minimum of 3 years of experience working as a pharmacometrician, or QSP modeler within pharmaceutical industry.
• Experience in developing Population PK, PK / PD, exposure-response, QSP, disease progression modeling and other model based-analyses to aid in research and development decision making.
• Proficiency in R, NONMEM, Python, MATLAB or other similar programing languages.
• Experience in developing advanced analytics that includes predictive, prescriptive & machine learning capabilities is a big plus
• Excellent communication, multitasking, and collaboration skills
• Experience in gene therapy and rare diseases is a plus, but not required.

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What Now?

We're always looking for solution-oriented, critical thinkers.

So, if you're comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.

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This position is remote. However, you will be expected to work on site at one of Sarepta's facilities in the United States and / or attend Company-sponsored in-person events from time to time.

The targeted salary range for this position is $132,000 - $165,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges.

The salary offer is commensurate with Sarepta's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity / Affirmative Action employer and participates in e-Verify.