Postdoctoral Fellow - Cancer Virology, T Cell Immunology, Structural Biology

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope , where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses.

Our dedicated and compassionate faculty and staff are driven by a common mission : Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

If you are looking for a challenging and exciting opportunity to advance your research career in cancer and virology, we invite you to join Dr.

Javier Gordon Ogembo’s multi-disciplinary lab. Our lab is part of the Beckman Research Institute of City of Hope, a world-renowned National Comprehensive Cancer Center located just 20 miles from Los Angeles.

City of Hope provides access to state-of-the-art facilities and resources excellent for transitional science, as well as a vibrant and collaborative research community.

The Beckman Research Institute of City of Hope has several facilities that are approved by the FDA for the production of investigational drugs and biologics for use in clinical trials.

These facilities are designed to meet rigorous regulatory standards and ensure the safety and efficacy of products developed at City of Hope.

For more information about Dr. Ogembo’s lab, please visit here.

As a successful candidate :

• You will have the opportunity to access state-of-the-art facilities and resources and work alongside leading experts in the field, contributing to cutting-edge research projects aimed at advancing our understanding the mechanisms of viral entry, oncovirology, vaccinology, and studying the interactions between viruses and host cells.
• In addition to the opportunity to work on exciting research projects, you will have access to City of Hope’s excellent benefits, and a supportive work environment that encourages career development and advancement.

Qualifications

Required qualifications :

or MD / degree(s) in a related field.

• Cell culture and aseptic technique : culture, handling, and maintenance of bacterial and mammalian cells (multiple cell lines), cryopreservation.
• Immuno-assays : western blot, ELISA, flow cytometry, immunofluorescence assay, immuno-histochemistry.
• Virology assays : virus production and titration, virus neutralization, plaque assays.
• DNA / RNA assays : DNA / RNA isolation from cells, viruses, and tissue, conventional PCR, qPCR, RT-qPCR, single cell RNA analysis.
• Pre-clinical animal models : animal handling (mice and / or rats), immunization / challenge, bodily fluid / blood collection, tissue processing.
• A track record of scientific productivity manifested in at least 2-3 first author publications in peer-reviewed journals.
• Ability to work independently and as part of a dynamic team.
• Previous experience working in a GLP / cGMP- compliant laboratory settings will be an added advantage.

Candidates must meet the required qualifications as well as possess the experience and techniques listed below for consideration into one of the four specialized areas in this lab :

Gamma-herpesvirus vaccine development :

Experience with gammaherpesvirus biology, and / or developing, handling and characterizing mRNA / DNA, virus-like particles, viral vector, and / or nanoparticle vaccine candidates, including lipid nanoparticles formulations.

Gamma-herpesvirus T cell immunology and therapeutics :

Immune cell assays : immune cell isolation (animal tissue, PBMCs), ex vivo T cell stimulation and proliferation assays, cell viability and metabolic activity assays, ELISPOT, cell migration assays, phagocytosis assays, multi-color flow cytometry immune panel analysis, and cytotoxicity assays.

Gamma-herpesvirus protein and antibody structural studies :

Protein assays : protein production and purification, crystal structure, cryo-electron microscopy, nuclear magnetic resonance, circular dichroism (CD) spectroscopy, mass spectrometry, surface plasmon resonance.

Use of preclinical animal models to assess gamma-herpesvirus entry mechanism and vaccine development :

• Previous experience working with non-human primate samples.
• Previous experience working with the humanized mouse model.

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here .

To learn more about our Comprehensive Benefits, please CLICK HERE .