Summary
This Associate Research Scientist / Senior Associate Research Scientist will join the Translational Development Group in San Diego.
The incumbent will be responsible for drug screening, cell-based assay development, and biomarker discovery. The individual will be responsible for execution of defined experiments and data analysis.
The position will require handling of tumor cell lines, blood samples and patient derived tissues. The associate will be expected to maintain an electronic lab notebook and organize results into reports or presentations.
The ideal candidate will possess strong communication, presentation, writing and record keeping skills. The successful candidate will have a proven technical and scientific track record and experience working in a multi-disciplinary team environment.
Responsibilities will include, but are not limited to, the following :
- Semi-independently execute defined experiments, data analysis and data QC
- Report on scientific results to meet project deadlines
- Work at the bench to develop and execute established and novel molecular and cell-based assays for drug screening as well as understanding molecular pathways (Proliferation, Apoptosis, Flow Cytometry etc.)
- Perform cell biology and molecular biology including primary and tumor cell culture, lentiviral transductions, RNA and protein preparation from cells and tissue, RT-PCR, western blotting, and ELISA.
Some training may be provided
- Hands on experience in working with CRISPR, siRNA and shRNA is a plus. Training will be provided.
- May involve handling and processing patient derived tissues and blood samples
- Collaborate effectively and cultivate positive and productive relationships with other scientists
- May involve presentation of data to manager and project team
- Thoughtful review of data and help plan next steps
- Participate in maintenance of routine laboratory instrumentation and supplies
- Adherence to laboratory safety policies and practices
The candidate should :
- Have a Bachelors degree in a scientific discipline with at least 2-4 years work experience
- Demonstrate proficiency with sterile cell culture, cell-based assays (CTG, apoptosis) and molecular biology techniques (Protein, DNA and RNA isolations, Western blot, qRT-PCR, Flow Cytometry)
- Experience with high-throughput drug screening is a plus
- Possess some trouble shooting and problem-solving skills to resolve technical questions in a multi-disciplinary environment
- Be able to work in fast paced environment with changing priorities
- Possess excellent communication, organization skills and attention to detail
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