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Post-doctoral position at UCSF Cancer Center in mechanisms of cancer drug resistance
Post-doctoral position at UCSF Cancer Center in mechanisms of cancer drug resistance
Location :
Helen Diller Family Cancer Research Building
Are you ready to apply Make sure you understand all the responsibilities and tasks associated with this role before proceeding.
1450 Sutter Street
San Francisco, CA 94158
United States
Job Posted Date : October 4, 2024
October 4, 2024
Population : Life Sciences
Life Sciences
The University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center (Mission Bay campus) is seeking candidates for the position of Postdoctoral Fellow to undertake studies to identify and characterize therapy-induced rewiring of high plasticity state drug resistant cells within chemically induced mouse cSCCs (see Taylor, Kandyba et al Science 2024 doi : 10.
1126 / science.adi7453). Candidate will join a collaborative, multidisciplinary team and will have the opportunity to conduct both basic and translational research.
This project will address a major problem in clinical oncology, namely the identification of critical drivers for development of cancer drug resistance.
Most tumors develop resistance to almost every type of therapy, including targeted-, radiation-, chemo- and immunotherapy, ultimately resulting in cancer deaths.
Some pathways pivotal to development of drug resistance have been identified using in vitro approaches, with a core of factors that are shared regardless of the organ site, tumor type, or therapeutic.
We will address mechanisms of resistance to both chemotherapies and immunotherapy, and compare data generated from the mouse with tumor material from patients undergoing such therapies for their cancer, specifically unresectable or metastatic cSCCs of the head and neck region.
The approaches we are taking include in vivo drug dosing of primary carcinomas that are induced in situ by chemical carcinogenesis.
We will examine anti-tumor drug efficacy and molecular responses to therapy by undertaking transcriptomic analysis, flow cytometry / CYToF analysis for immune cell composition, and multicomponent spatial analysis (Xenium and multi-IFC).
Comparison with human SCCs undergoing treatment, and with use of different treatment modalities will be made. Transcriptional signatures that define high plasticity drug resistant states will be generated by metagene analyses (doi : 10.
1126 / science.adi7453). Combinatorial drug treatments and / or CRISPR / Cas technology will be utilized to explore vulnerabilities of these drug resistant cell states to drug combinations or combinatorial gene KO.
Job Requirements :
The candidate must have an advanced degree and experience in one or more of the following areas : molecular and cellular biology, in vivo mouse models of cancer, biocomputational approaches to gene expression analysis, and CRISPR Cas9 screens.
They will join a collaborative, multidisciplinary team and will have the opportunity to conduct both basic and translational research.
The ideal applicant will have recently obtained a PhD using small animal models of cancer, and have a strong track record of publications, teamwork, and collegiality.
Such a person would be encouraged to apply for post-doctoral fellowships as part of their individual career development plan and they will receive strong mentorship.
How to Apply :
To apply for the Post-doctoral fellowship and for more information : contact Rosemary Akhurst at [email protected].
Please send 1) your Curriculum Vitae, 2) statement of research interests, and 3) the names of 3 references to Dr. Rosemary Akhurst at [email protected].
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