Sr. Associate Scientist
Job Title : Sr. Associate Scientist, RNA Process Development
While professional experience and qualifications are key for this role, make sure to check you have the preferable soft skills before applying if required.
Location : Seattle, WA
Compensation : $53.34 -$67.74
Type : Contract
Responsibilities
- Design and execute nucleic acid ligation reactions using splint ligation methodology
- Design and execute ion-pairing (IP) reversed-phase (RP) chromatography methods
- Perform purification of oligonucleotides using chromatography and / or preparative PAGE
- Design and evaluate the performance of new biophysical assays to identify and assess CQA’s
- Manage samples and data related to gene editing platform process development
- Provide experimental design and executional support to team members in adjacent and related functions (e.g. clinical development programs, high throughput process development, etc.)
- Actively participate and support lab maintenance and continuous improvement initiatives
- Maintain accurate and detailed laboratory notebook and documentation
- Summarize and present data in group meetings and contribute to group discussions
- Author technical reports, study memos, and protocols
Requirements
- STEM degree with 2+ years of relevant industry experience; title / compensation will be commensurate with education, experience, and skillset
- Proficiency with biochemical techniques to analyze oligonucleotides (PAGE and CE)
- Proficiency with analytical IP-RP chromatography for RNA (including mRNA) purity
- Experience working with, storing, and analyzing purified nucleic acids and proteins
- Independently motivated with the ability to work in teams
- Ability to communicate clearly and concisely through oral presentation and technical writing
- Ability to leverage literature, internal and external resources to solve problems and develop new technologies
- Possess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environment
Preferred Qualifications :
- Degree in biological or chemical engineering, biochemistry, or bio-related field
- Experience with optimizing molecular cloning reactions
- Experience with gene editing primary human cells or immortalized cell-lines
- Experience with solid-phase oligonucleotide synthesis
- Experience with bioinformatic tools used to predict RNA secondary structure
- Experience with JMP for DoE design and analysis
Benefits
System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.
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