Senior Research Associate, Oligonucleotide Chemistry

Stoke Therapeutics (Nasdaq : STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels.

Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome.

Stoke has identified STK-002 as a clinical candidate for the potential treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The company is also pursuing a potential new medicine for Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Position Purpose :

We are seeking a dedicated and highly motivated senior research associate in oligonucleotide chemistry to join a dynamic team focused on advancing oligonucleotide-based therapeutics. Within the chemistry team, you will work with talented scientists on the synthesis of bioactive oligonucleotides for our drug discovery programs and delivering to the project teams with strict timelines while reporting to your manager.

Key Responsibilities :

• The role is primarily responsible for supporting the automated synthesis, cleavage, deprotection, purification, analysis and packaging of oligonucleotides, including heavily modified oligonucleotides.
• Maintaining laboratory equipment, including the oligonucleotide synthesizer, HPLC machines and benchtop equipment to ensure consistent and reliable oligonucleotide production.
• Performing critical evaluation and optimization of the processes to improve synthesis yield, purity and timelines for production of modified oligonucleotides
• Manage ordering and organization of chemicals and supplies necessary for oligonucleotide synthesis
• Analyzing and interpreting data as well as writing technical reports and protocols, with supervision. Presents research results at lab meetings.
• Keeps up to date on relevant scientific literature and developments to support ongoing research efforts.

Required Skills & Experience :

Location(s) :

Stoke operates in Bedford, MA. This position is a lab-based position in our Bedford, MA location.

Travel :

This position will require approximately 5% travel.

Culture & Values :

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Benefits & Compensation :

At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.

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