Research Associate/Senior Research Associate, mRNA Process Development

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Your experience includes

• BS / MS with 0-3 years of experience in Biochemistry, Molecular Biology, Chemistry, Analytical Chemistry, or related discipline.
• Technical understanding and experience in mRNA process development including mRNA synthesis, purification and analysis.
• Hands-on experience with in vitro transcription (IVT) and mRNA purification technologies (beads or columns).
• Understanding of nucleic acid biochemistry, enzymatic and chemical reactions, PCR reaction, plasmid processing, and standard analytical techniques for macromolecules is preferred.
• Track record of completing deliverables within specified timelines.
• Eager to work with highly skilled and dynamic teams in a fast-paced, entrepreneurial and technical setting.
• The successful candidate should be collaborative, communicative, and passionate about the next generation of genetic medicines.

Preferred Qualifications

• Experience in using analytical technologies including nanodrop, Tape station, Lunatic, Fragment analyzer, capillary electrophoresis.
• Experience with magnetic beads and column-based mRNA purification (HPLC, AKTA).
• Experience with handling automated systems like Kingfisher, TECAN, Hamilton, or a desire to learn.
• Experience with Design of Experiment (DOE) statistical tools for process improvement.

You are interested in

• Develop and innovate mRNA synthesis using enzyme catalyzed reactions such as restriction digestion, in vitro transcription (IVT) and mRNA purification.
• Learn and execute automation instruments including liquid handlers (TECAN, Kingfisher) for automated high throughput miniature reactions and purification.
• Analyze mRNA quality by nanodrop, tape station, fragment analyzer etc.
• Support the generation of preclinical mRNA high quality material and collaborate with cross-functional teams.
• Maintain thorough electronic lab notebooks and documentation records (e.g. Benchling).
• Adhere to all laboratory safety requirements and procedures.

About you :

Tessera Therapeutics is seeking a Research Associate / Senior Research Associate for RNA process development and innovation.

You will support process development for in vitro transcription, modification, and purification of RNAs to support Tessera's pre-clinical efforts.

We seek scientists who are proactive, enthusiastic, and show a passion for process development. The successful candidate should have strong communication and collaboration skills.

Strong attention to detail and excellent organizational and documentation skills are highly desirable.

Tessera employees are creative and collaborative problem solvers with a strong sense of integrity and unwavering commitment to scientific excellence.

Company Summary :

Tessera Therapeutics is pioneering Gene Writing a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source.

Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy.

Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

More about Tessera Therapeutics :

Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate.

Tessera provides reasonable accommodations to qualified applicants and employees with disabilities.

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