Scientist, LNP
Job Description
Our client is seeking a candidate with experience in formulation and downstream processing of lipid nanoparticles, stability evaluation of LNPs, and in vitro and in vivo assessment of the LNP systems.
The candidate will join as a SRA / Scientist with the process sciences team to develop formulations for its CRISPR by Design™ platform.
The ideal candidate should have a good understanding of lipid nanoparticle formulations by various mixing and downstream processing techniques.
- Key Responsibilities Formulate and characterize lipid nanoparticle (LNPs) formulations both at small and intermediate scales.
- Follow SOPs and perform in-process and release analysis of manufacturing operations. Perform set-up and cleanup of equipment and manufacturing space.
- Assist team to generate LNP formulations for in-house and R&D requirements.
- Perform analysis of formulations using; UPLC-UV, UPLC-CAD, LC-MS, CGE, DLS, plate-based assays, gels, pH, osmolality, and endotoxin.
- Data analysis using statistical software’s such as GraphPad PRISM, JMP etc.,
- Effectively collaborate within various groups and map out future needs and manage procurement of materials.
- Maintain detailed records of experimental protocols and data in electronic laboratory notebook.
- Additional duties and responsibilities as required will be assigned based on the needs of the team.
- Required skills and background : BS with 5+ years of experience, or MS / PhD with 3+ year of experience in an industry setting.
Degree in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences, or related discipline.
- Experience with downstream processing, such as dialysis, Tangential Flow Filtration (TFF), ultra-filtration and sterile filtration techniques.
- Experience with drug delivery and RNA are an asset.
- Excellent collaborative, communication skills and a good team player.
Preferred Skills :
- Familiarity with CRISPR technologies and therapeutic approachesKnowledge of lipid nanoparticles, analytical characterization of lipids and nucleic acid payloads
- Ability to run methods and characterization techniques such as Particle size analysis, RNA content analysis, Osmometer, Agarose-Gel, Western Blot, UV-Vis Spectroscopy, UPLC-CAD, UPLC-UV, fragment analyzer, ELISA, 96 well plate-based assays.
- Knowledge and experience using GraphPad, JMP are preferred.
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