A postdoctoral position is available in the lab of Dr. Andrew J. Murphy in the Department of Surgery at St. Jude Children’s Research Hospital ( / labs / murphy-andrew-jackson-).
The Murphy lab focuses on basic and translational scientific research that seeks to benefit high-risk subsets of patients with Wilms tumor, the most common pediatric kidney cancer.
Our patient groups of emphasis include those with anaplastic Wilms tumor, bilateral Wilms tumor, and relapsed favorable histology Wilms tumor with chemotherapy resistance.
We seek to better understand how intratumor histologic and genetic heterogeneity evolve with chemotherapy treatment in Wilms tumor and may differ among multifocal or bilateral tumors in the same patient.
We also seek to understand how epigenetically mediated blastemal-epithelial-mesenchymal plasticity relates to chemotherapy resistance and how it can be overcome using small molecule inhibitors of epigenetic modifiers.
We are seeking a Postdoctoral Associate whose research will study intratumor histologic, genetic, and epigenetic heterogeneity in Wilms tumor samples as part of the biology aims of our ongoing institutional Wilms tumor clinical trial SJWT21.
Part of this approach will be comparing drug sensitivity between paired organoid, tumor spheroid, and patient-derived xenograft models from the same patient source.
Candidates with training in molecular biology, cell biology, cancer biology, and molecular genetics are welcome to apply.
Minimum Qualifications
Ph.D. in molecular biology, cell biology, cancer biology, genetics, or a related field.
No experience required
Diversity, Equity and Inclusion
St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion.
Our founder Danny Thomas envisioned a hospital that would treat children of the world regardless of race, religion or a family’s ability to pay. .
Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment.
As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success.
With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive.
View our to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.
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