Senior Research Associate, Genomic Medicines, Vector Development and Operations

This is what you will do :

The Senior Research Associate will work within the Vector Development and Operations team on projects related to capsid engineering and AAV manufacturability advancement.

The successful candidate is expected to produce research-grade rAAV vectors and manage the production requests according to portfolio prioritization.

The candidate will manage and contribute to the documentation of the AAV production and coordination for the AAV vector characterizaiton.

In addition, you will collaborate with scientists contributing to capsid design, generation of novel capsid libraries, library screening and related assays to develop AAV vectors with improved properties for therapeutic applications.

They will also work closely with scientists in developing and validating novel technologies to improve AAV vector manufacturability.

The candidate must possess good verbal, written, and communication skills.

You will be responsible for :

• Manufacturing research-grade rAAV vectors utilizing suspension cell culture in shaker flasks. Fulfill the vector production requests and internal production prioritization in the timely manner.
• Supporting scientists to optimize AAV capsids by targeted and / or random modifications based on capsid structural biology and library generation;

developing molecular biology-based methods for library screening in vitro and in vivo.

• Executing processes for purification of rAAV utilizing various techniques such as depth filtration, centrifugation, column chromatography and TFF.
• Performing analytical tests such as qPCR / ddPCR, SDS-PAGE, infectivity assays as required.
• Filling out batch records, and accurately completing documentation associated with preclinical manufacturing.
• Providing technical support to early development and process development activities when appropriate.
• Collaborating with the Analytical Development team to characterize AAV vectors and verify comparability of vector attributes between different expression systems.
• Participating in internal scientific forums to provide regular updates about the progress of actvities your conduct.
• Maintaining electronic labaratory notebook entries in compliance with SOPs.

You will need to have :

• Bachelor's or Master Degree in Engineering, Biotechnology, Biology, Biochemistry, Virology or related science discipline with a minimum 2 year of relevant experience in the field of gene therapy, preferably AAV
• Understanding of scientific principles and think critically to problem solve and troubleshoot results
• Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment
• Ability to multi-task to meet the company goals
• Excellent organizational and communication skills

We would prefer for you to have :

• Cell culture and molecular biology experience
• AAV viral vector production experience

Date Posted

27-Sep-2024

Closing Date

28-Nov-2024Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness.

The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law.

Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding an accommodation, please contact Alexion participates in E-Verify.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.