Postdoctoral Research Fellowships - In Vivo Microscopy-(3278958)
Description
Postdoctoral Research Fellowships (In-vivo Microscopy)
Employer Description
Guillermo (Gary) J. Tearney, ., .
Tearney Lab Wellman Center for Photomedicine
Massachusetts General Hospital
The Tearney Lab is an 80+ person multidisciplinary lab led by Guillermo (Gary) Tearney, MD, PhD. The goal of the Tearney Lab is to see every cell in the human body so that disease can be detected at its earliest stages when it can be cured.
To this end, the lab has pioneered multiple optical coherence tomography (OCT) devices that enable 3D imaging at the microscopic scale in living human patients.
These technologies include multimodality OCT where OCT is combined with spectroscopy, fluorescence, and other optical techniques, ultrahigh-resolution OCT (µOCT) where the resolution is sufficiently detailed to visualize individual cells, and functional OCT that measures the function and metabolism of cells in living systems.
These technologies are implemented in a variety of devices (endoscopes, catheters, capsules, implantable) that provide accessible imaging anywhere inside the body.
The lab has major programs to overcome clinical diagnostic challenges in celiac disease, food allergy disorders, malnutrition, coronary artery disease, hearing loss, GI cancer, and cystic fibrosis, among others.
Novel technologies are created using device development processes and tested and validated in over 15 ongoing single- and multi-center clinical studies.
To enable this broad translational research, the Tearney Lab is outfitted with :
- Robust engineering, quality, and clinical regulatory teams
- State-of-the-art optical laboratories
- Two class 10,000 clean rooms
- Multiple rapid prototyping facilities
- Nanoscribe optical printing
- Machine learning core
Job Description
The role will :
Develop novel fiber optic probes, develop novel illumination and detection systems with suitable sensitivities for biological imaging
Develop novel optical devices based on optical modalities such as spectrally encoded confocal microscopy, multi-photon microscopy, and photoacoustics.
Develop novel OCT based-devices for in-vivo imaging including high-resolution micro-OCT, dynamic OCT, fluorescence OCT, white light OCT, diffuse reflectance OCT, and OCT combined with ultrasound
Implement technologies in one or more of the following organ systems : heart, lungs, brain, ears, and the gastrointestinal tract
Guide research questions, design studies, and monitor the execution of those studies
Guide and oversee engineers and technicians on the research aspects of your projects and ensure they are being done to a scientifically valid and publishable standard
Hold regular technical meetings, set the agenda, and outline a sequence of work for technicians and engineers to follow
Publish in world-leading high impact journals
Deliver milestones on time
This appointment will be made at the rank of postdoctoral fellow or instructor at Harvard Medical School, commensurate with the applicant’s experience.
MGH’s role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for developing and translating new OCT technologies with applications in basic and clinical research.
Representative recent publications from our group include :
1. Dong, J., C. Grant, B. Vuong, N. Nishioka, . Gao, M. Beatty, G. Baldwin, A. Baillargeon, A. Bablouzian, P. Grahmann, N.
Bhat, E. Ryan, A. Barrios, S. Giddings, T. Ford, E. Beaulieu-Ouellet, . Hosseiny, I. Lerman, W. Trasischker, R. Reddy, K.
Singh, M. Gora, D. Hyun, L. Queneherve, M. Wallace, H. Wolfsen, P. Sharma, . Wang, . Leggett, J. Poneros, . Abrams, C. Lightdale, S.
Leeds, M. Rosenberg, and . Tearney, Feasibility and Safety of Tethered Capsule Endomicroscopy in Patients With Barrett's Esophagus in a Multi-Center Study.
Clin Gastroenterol Hepatol, 2022. 20(4) : p. 756-765 e3.
2. Wartak, A., . Kelada, . Leon Alarcon, . Bablouzian, . Ahsen, . Gregg, Y. Wei, K. Bollavaram, . Sheil, E. Farewell, S.
VanTol, R. Smith, P. Grahmann, . Baillargeon, . Gardecki, and . Tearney, Dual-modality optical coherence tomography and fluorescence tethered capsule endomicroscopy.
Biomed Opt Express, 2021. 12(7) : p. 4308-4323.
3. Osborn, ., . Ughi, . Verjans, Z. Piao, E. Gerbaud, M. Albaghdadi, H. Khraishah, . Kassab, . Takx, J. Cui, A. Mauskapf, C.
Shen, . Yeh, . Klimas, A. Tawakol, . Tearney*, and . Jaffer*, Intravascular Molecular-Structural Assessment of Arterial Inflammation in Preclinical Atherosclerosis Progression.
JACC Cardiovasc Imaging, 2021. 14(11) : p. 2265-2267.
4. Yin, B., Z. Piao, K. Nishimiya, C. Hyun, . Gardecki, A. Mauskapf, . Jaffer, and . Tearney, 3D cellular-resolution imaging in arteries using few-mode interferometry.
Light Sci Appl, 2019. 8 : p. 104.
5. Leung, ., . Birket, C. Hyun, . Ford, D. Cui, . Solomon, . Shei, . Adewale, . Lenzie, . Fernandez-Petty, H. Zheng, . Palermo, .
Cho, . Woodworth, . Yonker, . Hurley, . Rowe, and . Tearney, Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies.
Sci Transl Med, 2019. 11(504).
Qualifications
Job Requirements
A PhD (or equivalent) in Biomedical Engineering, Electrical Engineering, Physics, or a related field is required.
Required Skills
Demonstrated excellence in one of the various forms of optical coherence tomography, confocal microscopy, or other in vivo microscopy techniques is required
Expertise in one or more of the following areas is desired : optical imaging systems, optical design, circuit design, optical system fabrication, fiber optic systems and components, broadband light source development, spectroscopy, image processing, programming, and clinical studies with novel devices
A strong grounding in fundamental optics theory including fiber optic light guides
A strong understanding of tissue optical properties
Desired Skills
Experience in modeling of light / tissue interactions
A background in fiber probe design (., ball lens, grin lens) including proximal and distal scanning
Strong computational background
A practical understanding of hardware control of optical and related instrumentation to include a working understanding of analog / digital circuits
Experience with real-time processing of optical data
An organized and creative problem-solver
Contact Information
Interested candidates are encouraged to send a CV accompanied by a cover letter describing any previous research training, specific areas of interest, and contact information for three letters of reference.
Address correspondence to Dr. Gary Tearney, note the position you are applying for in the subject line, and send by email to
MGH is an equal opportunity employer.
Research Scientist, Cell Engager Therapies In Vivo Pharmacologist
Join Takeda as a Research Scientist, Cell Engager Therapies In Vivo Pharmacologist where you will be responsible for the discovery and development of novel therapeutics in the T cell engager space supporting new and ongoing pipeline programs. Experience culturing and maintaining human tumor cell lin...
Senior Research Associate, In Vivo Beta Islet Team
We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic informa...
Research Associate, In Vivo Pharmacology
We are seeking a Research Associate in In Vivo Pharmacology to conduct rodent studies supporting Platform Science research. Since our founding in 2010, we have aspired to build the leading mRNA technology platform, theinfrastructure to reimagine how medicines are created and delivered, and a world-c...
Research Senior Scientist, Antibody Discovery & Engineering, In Vivo Based Methods
You will include deep scientific engagement and involvement in programs; defining the best path forward based on the therapeutic needs, designing immunization strategies, performing immunizations/animal handling and tissue harvest, and conducting HT antibody discovery using technologies using single...
In Vivo Research Scientist
Sanofi’s US In Vivo Research Center (IVRC) within the Translational Models (TIM) Research Platform plays a key role in advancing the global research pipeline. Bachelor’s Degree plus minimum 6 years of relevant research experience in an academic or biopharmaceutical setting OR Master’s Degree plus mi...
Sr. / Principal Research Associate In Vivo
Principal Research Associate to join our client's In vivo team for a 6 month contract assignment based in Lexington, United States. Rodent Handling/Husbandry Management - monitoring animals' health status daily; administering treatments when necessary; maintaining accurate records on study data shee...
Postdoctoral Fellowships in Cardiac Cell and Tissue Engineering
Applications of machine learning in cell and tissue engineering. The Disease Biophysics Group is a creative, transdisciplinary group of engineers, scientists, clinicians and artists that work at the intersection of art, cell biology, design, materials science, and computational modeling. Disease Bio...
Research Associate II, Immunology, In Vivo
Support the execution of in vivo experiments in multiple mouse models across diverse therapeutic areas including inflammatory diseases, autoimmunity, transplantation, and neurology related diseases under guidance and supervision. Experience with in vivo mouse handling, with multiple routes of inject...
Postdoctoral Research Fellow Position in Geophysics/Earthquake Science
Research projects will be focused on imaging earthquake cycle kinematics, statistical earthquake cycle models, large-scale data integration, and novel dynamical systems modeling. The appointment is initially for one year with the possibility of an extension for two more years for a total of a three-...
Postdoctoral Research Fellowships (Near Infrared Fluorescence Intravascular Ultrasound)
Collaborate with interdisciplinary teams of scientists, clinicians, and engineers to develop a viable pathway to integrate molecular imaging technologies into clinical practice. MGH’s role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide ...