Bioinformatician I

Department

BSD PED - Cardiology - Moskowitz Lab

About the Department

Exciting research opportunity in the Moskowitz laboratory to help drive a research project in developmental biology aimed to understand the molecular basis of birth defects.

The lab is devoted to the genetic, genomic and molecular study of gene regulatory networks in developing organs, particularly cardiac development with respect to congenital heart disease (CHD).

In cardiac development, we have identified an essential role for cilia-based Hedgehog signaling in cardiac progenitors, an essential aspect of mammalian cardiac development.

Our studies have contributed to a paradigm shift in the understanding of cardiac morphogenesis, which is driven by events in cardiac progenitors rather than in the heart itself (e.

g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in developmental timing control that will be the basis of future projects (Rowton et al. 2020).

Job Summary

The Moskowitz Lab is looking for a Bioinformatician 1; the job administers programs and support all phases of bioinformatics activities by helping devise or modify procedures to solve biological complex problems.

The Bioinformatician 1 is responsible for all aspects of research projects and research facilities. Plans and conducts clinical and non-clinical research;

facilitates and monitors daily activities of research projects. Directs engineering and technical support activities to develop and maintain tools and computational methods needed to gather and analyze data.

This at-will position is wholly funded by contractual grant funding which is renewed under provisions set by the grantor of the contract.

Employment will be contingent upon the continued receipt of these grant funds and satisfactory job performance.

Responsibilities

Knowledge and experience in basic and advance analyses of NGS data (ChIP-seq, RNA-seq, ATAC-seq, Hi-C, Bisulfite sequencing, etc.).

Designs and perform formal evaluation of informatics methods and products.

Manipulates publicly accessible, commercial, or proprietary genomic, proteomic, or post-genomic databases.

Participates in creating data algorithms and specialized computer software to identify and classify components of a biological system (i.

e. DNA and protein sequences).

Applies basic application of computational tools and information technology to gather, analyze and visualize data in biology and biomedical research.

Interprets data analysis of high throughput genomics, proteomics, and genetic data.

Plans own resources to implement or modify existing web-based bioinformatics tools.

Performs other related work as needed.

Minimum Qualifications

Education :

Minimum requirements include a college or university degree in related field.

Work Experience :

Minimum requirements include knowledge and skills developed through 2-5 years of work experience in a related job discipline.

Certifications :

Preferred Qualifications

Education :

Bachelors in bioinformatics, Computational Biology, Computer Science, Mathematics, or a related field.

Master’s degree.

Experience :

Author of at least one research article where the candidate contributed to bioinformatics analyses.

Experience in single cell genomic analyses.

Preferred Competencies

ChIP-seq, ATAC-seq, GRO-seq, and RNA-seq.

CRISPR genetic engineering.

Rapid protein degradation using Degron system.

Bioinformatics.

Cardiac functional analyses.

Mouse genetics.

Lentivirus transduction.

Cell culture experience.

Protein-protein interaction analysis using mass-spectrometry.

Working Conditions

Laboratory Setting.

Application Documents

Resume (required)

Cover Letter (required)

References (preferred)

When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application.

Job Family

Research

Role Impact

Individual Contributor

FLSA Status

Exempt

Pay Frequency

Monthly

Scheduled Weekly Hours

Benefits Eligible

Drug Test Required

Health Screen Required

Motor Vehicle Record Inquiry Required

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