Principal Platform Architect

About Karius Karius is a venture-backed life science startup focused on transforming how infectious diseases are diagnosed.

Combining Next-Generation Sequencing and proprietary data analysis, we can identify over 1,000 human pathogens from a single blood sample with a typical turnaround time of one business day.

By unlocking the information present in microbial cell-free DNA, we're helping doctors quickly solve their most challenging cases, with a future vision of accelerating clinical trials, discovering new microbes, and reducing patient suffering worldwide.

Position Summary Research, development, and operation of Karius’s novel technologies heavily depend on the underlying computing and data infrastructure, software system architecture, and various research and engineering tools (aka, Karius R&D / Ops platform or simply Platform ).

In this critical engineering role, you will collaborate closely with the engineering and science leadership to set the strategic direction for the technology behind this Platform.

Then, develop and drive a technology roadmap to develop and operate an extensible, reliable, secure, and scalable Platform.

Why Should You Join Us? Karius’ core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning.

The company’s platform already delivers unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood.

Through this journey, we have repeatedly innovated beyond state-of-the-art to deliver critical insights from our new data type - microbial cell-free DNA.

You, as an impactful and influential member of one of Karius’ most innovative teams, will be able to impact and drive critical elements in our core engineering platform and will be able to see significant implications of this work on patients suffering from infectious diseases and beyond.

Reports To : Vice President, Engineering*This position is not open to agency support at this time. Agencies, please get in touch with < and not the hiring manager for inquiries.

Location : Redwood City, CA or Hybrid Primary Responsibilities

• Leading architectural projects from concept to completion, ensuring timely delivery and adherence to budget and quality / regulatory requirements.
• Developing architectural blueprints, frameworks, and guidelines for Platform development and operation.
• Ensuring the architecture meets technical and business requirements including security, performance, interoperability, and scalability.
• Staying current with industry trends and emerging technologies to ensure the
• Platform leverages the best technologies that fit the needs.
• Articulating and presenting complex ideas clearly and effectively to technical and business audiences.
• Developing, documenting, and organizing artifacts such as strategy, technical proposals and designs, and risk assessments.
• Ensuring Karius’s R&D and engineering staff have the proper infrastructure, tools, and processes to be productive.
• Ensuring the Karius Platform is cloud vendor agnostic, can be provisioned globally using a blueprint as code, and meets regional privacy and security rules and regulations.
• Enable the Platform to be provisioned for non-Karius laboratories, enabling them to operate Karius products. What’s Fun About the Job?

Karius is operating at the edge of what is now possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities.

To deliver on that value, you will be tapping into advanced technologies, architecting, and innovating where the current out-of-the-box solutions simply don't suffice the complexity and scale we operate at.

If you enjoy building Swiss-watch -like distributed systems while needing to improvise often to address new and unique challenges, you will have fun in our team.

Ultimately, this role has a broad technical and organizational influence and can multiply the knowledge and skills of the Karius engineering, science, and operation teams with the innovations built into the Platform.

Travel : Travel required up to 10%. Physical Requirements Subject to extended sitting and standing periods, vision to monitor, and moderate noise levels.

Work is performed in an office environment. Position Requirements Primarily, show us you have successfully built and operated several complex, high-quality, regulated, reliable, and scalable R&D and engineering cloud-native platforms.

Convince us that you have the technical, people, and organizational skills to understand and translate complex business and technical requirements into a one-of-a-kind platform that becomes a sustaining competitive advantage for Karius.

or in Computer Science, Electrical Engineering, Physics, Statistics, Biomedical Engineering, Genetics, or a related engineering or science field.

in these fields is a big plus.

• 15+ years of engineering experience, 10 of which in leading the development and operation of distributed software systems and cloud-native platforms.
• Proficient in infrastructure-as-code design and tools such as Terraform.
• Deep knowledge and experience in design patterns, implementation, testing, and failure management of distributed systems and microservices.
• Hands-on experience with cloud-native software development and operations approach; primarily using tools and technologies such as Docker, Kubernetes, and Cloud services to run software services and data analytics jobs.
• Proficient in industry security standards such as NIST CSF / SSDF with hands-on experience implementing and monitoring cloud security controls.
• Experience with various code flow and DevOps approaches such as gitOps.
• Lead architectural projects from concept to completion, ensuring timely delivery and adherence to budget and quality / regulatory requirements.
• Develop architectural blueprints, frameworks, and guidelines for Platform development and operation.
• Ensure the architecture meets technical and business requirements including security, performance, interoperability, and scalability.
• Stay current with industry trends and emerging technologies to ensure the Platform leverages the best technologies that fit the needs.
• Track record of building mutual trust, exerting cross-functional indirect influence, and leading change.
• Articulate and present complex ideas clearly and effectively to technical and business audiences.
• Develop, document, and organize artifacts such as strategy, technical proposals and designs, and risk assessments.
• Experience in healthcare and life sciences especially developing medical devices is a big plus. Personal Qualifications We want to add a humble, curious, and collaborative member to our team.

At the Karius engineering team, we highly value deep domain expertise, drive for innovation, desire to collaborate, being open to learning and unlearning, and passion for solving hard problems with a meaningful impact on the world.

A sense of ownership and personal / group accountability allows us to be a productive and high-performing team. If you share our vision we would like to have you on board.

At Karius, we value a diverse and inclusive workplace and provide equal employment opportunity for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company.

All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual’s race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws.

If you are unable to submit your application due to a disability, please contact us at and we will accommodate qualified individuals with disabilities. $210,000 - $290,000 a year