Research and Development Associate III
Duration : 12-month contract - potential extension
Location : Onsite in Cambridge, MA
What You’ll Do :
- Establish and perform in vivo PK / PD studies for therapeutic proteins, antisense oligonucleotides, viral vectors, and other modalities with CNS delivery / targeting properties.
- Perform in vivo immunizations to generate antigen-specific antibodies from B cells by next-generation sequencing or hybridoma production
- Contribute to research efforts on specific projects involving novel BBB targets and other modalities
- Perform biochemical and molecular biology assays to enable PK / PD analysis of therapeutic candidate drugs, including ELISA / MSD, and qPCR
- Work as a part of a collaborative and cross-functional team
- Perform data analysis, maintain electronic laboratory notebooks, and present data
Required Skills :
- EDUCATION level BS, MS, or Ph.D in Biochemistry, Analytical Chemistry or related major.
- Industry experience 3-5 years
- Expertise with in vivo procedures, including injections (IV, SC, IP), blood collection and necropsy / tissue collection (brain, spinal cord, muscle and other tissues)
- Experience with in vivo immunization techniques for antibody generation
- Ability to establish and perform biochemical and molecular assays, including ELISA / MSD, qPCR, BCA and other relevant techniques
- Strong communication, organization and documentation skills
- Quantitative data analysis using GraphPad Prism, MS Office or other relevant software.
Preferred Skills :
- Knowledge in BBB field and CNS delivery technologies including viral-delivery technologies and receptor-mediated transcytosis
- Knowledge of basic neurobiology, neurodegenerative diseases, and drug discovery
- Ability to establish and perform biochemical and molecular assays, including FACS and internalization assays using cellular imaging
- Experience with immunohistochemistry, histology and microscopy
- Experience in handling and working with large molecules
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