Based in Massachusetts
Upstream Process Development Scientist
My client is a growing CDMO with a focus on producing Adeno-Associated Virus (AAV) vectors. For gene therapy companies, they provide end-to-end solutions ranging from preclinical development to clinical and commercial manufacturing.
Their state-of-the-art facility in Massachusetts is committed to developing treatments for individuals with uncommon and unfulfilled medical requirements.
Responsibilities :
- Take the lead in creating and refining the upstream procedures for the production of AAV, such as virus propagation, transfection, and cell culture.
- Using bench-scale, pilot-scale, and large-scale bioreactors (e.g., 10L to 2000L) with both adherent and suspension systems, develop, optimise, and scale-up AAV production processes.
- The mission is to successfully scale up AAV processes from small-scale (shake flasks, micro bioreactors) to pilot and GMP manufacturing scale through the design and execution of trials.
Requirements :
- Master's degree with eight years of experience in a relevant discipline, or Ph.D. in Chemical Engineering, Biochemical Engineering, Biotechnology, or a related field with five years or more of industry experience.
- A great deal of upstream process development experience, especially in the manufacture of AAV and other viral vectors.
- Demonstrated practical experience with both adherent and suspension cultures in single-use and stainless steel bioreactors.
- A track record of successfully expanding AAV production processes from bench to pilot and factory levels.
- Knowledge of the transfection / infection techniques and cell lines (such as HEK293, Sf9) that are frequently utilised in the creation of AAV.
To discuss further call me at 857 400 7901 or email me at [email protected]
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