Bioconjugation Chemistry Scientist 1
Duties :
Synthesis, optimization, and high-quality delivery of various polymer, protein / peptide, and lipidated bioconjugates in support of discovery and development of Client therapeutics, with an emphasis on oligonucleotides
Development and implementation of new linker chemistries / spacers and bioconjugation methods for targeted drug delivery
Leveraging appropriate purification and analytical characterization approaches for QC and validation
Collaboration with internal and external partners for material transfer to support in vitro and in vivo POC experiments; assemble data packages and maintain quality control documentation through Benchling for final product delivery.
Effectively partner with cross-functional teams, sharing insights, troubleshooting issues, and driving science forward from the bench
Serve independently as bioconjugation technical lead and subject matter expert for internal and external project communications
Perform data analysis, interpret, and present results during internal and external meetings; attend and participate in scientific proceedings.
Prepare and optimize chemistry SOPs
Participate and present data and share responsibility for project milestones
Skills :
Extensive experience with different bioconjugation strategies and optimizations thereof for polymers, proteins / peptides, lipids, oligonucleotides and other biomolecules
In-depth experience in bioconjugate purification techniques including various liquid chromatography methods (e.g. RP, IEX, SEC, HIC, affinity, FPLC) and membrane filtrations (e.g. TFF)
Prior experience in biochemistry techniques and analytical methods such as SEC-MALs, LCMS, SPR / BLI, ELISA, SDS-PAGE, enzyme activity assays, etc.
Willingness to learn new bioconjugation chemistries or delivery modalities and work across diverse therapeutic areas to develop protein therapeutics.
Strong analytical mindset and chemistry problem-solving with creative thinking
The position requires organization skills, attention to detail, self-motivation, and strong teamwork in a fast-paced setting
Education :
Ph.D. in Chemical Engineering, Chemical Biology, Chemistry, or related fields is required; Scientist 1 will have 0-2 years of industry / post-doc experience relating to drug development
Strong foundation in macromolecular chemistry, bioconjugation, analytical chemistry and / or chemical biology is strongly desired.
A record of accomplishments / publications in relevant scientific discipline and some hands-on experience in oligonucleotide delivery is preferred but not required.
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