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Senior Scientist

Senior Scientist

Net2Source (N2S)San Diego, CA, United States
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Net2Source Inc. isn’t just another staffing company, we’re a powerhouse of innovation, connecting top talent with the right opportunities. Recognized for 300% growth in the past three years, we operate in 32 countries with a global team of 5,500+. Our mission? To bridge the talent gap with precision—Right Talent. Right Time. Right Place. Right Price.

Job Title : Scientist I, Oligonucleotide Analytics

Location : La Jolla, CA 92121

Duration : 12+ Months (Extendable)

Top Three Skills : Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughout analytical capabilities

Key Responsibilities :

30%

  • Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects

20%

  • Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
  • 10%

  • Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
  • 20%

  • Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
  • 5%

  • Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
  • Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
  • Support integrity confirmation requests (such as concentration) by assay development and biology teams
  • 3%

  • Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
  • 5%

  • Ensure the supply of laboratory consumaables and reagents are in stock as needed
  • Maintain a high level of productivity in the laboratory setting.
  • 2%

  • Present data and reports on project status at individual, group, and departmental meetings.
  • Qualifications

  • Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training / experience is required.
  • Prior experience in the characterization of oligonucleotides and / or nucleoside / nucleotide analytes is required.
  • Why Work with Us?

    We believe in more than just jobs—we build careers. At Net2Source, we champion leadership at all levels, celebrate diverse perspectives, and empower you to make an impact. Think work-life balance, professional growth, and a collaborative culture where your ideas matter.

    Our Commitment to Inclusion & Equity

    Net2Source is an equal opportunity employer, dedicated to fostering a workplace where diverse talents and perspectives are valued. We make all employment decisions based on merit, ensuring a culture of respect, fairness, and opportunity for all, regardless of age, gender, ethnicity, disability, or other protected characteristics.

    Awards & Recognition

    America’s Most Honored Businesses (Top 10%)

    Fastest-Growing Staffing Firm by Staffing Industry Analysts

    INC 5000 List for Eight Consecutive Years

    Top 100 by Dallas Business Journal

    Spirit of Alliance Award by Agile1

    Ready to Level Up Your Career?

    Click Apply Now and let’s make it happen.

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