Talent.com
Senior Scientist, Protein Engineering

Senior Scientist, Protein Engineering

SystimmuneRedmond, WA, US
job_description.job_card.30_days_ago
serp_jobs.job_preview.job_type
  • serp_jobs.job_card.full_time
job_description.job_card.job_description

Job Description

Job Description

SystImmune Inc. is a dynamic clinical-stage bio-pharmaceutical company headquartered in Redmond, WA. Our mission is to revolutionize cancer treatment by developing breakthrough-therapeutic multi-specific antibodies and ADCs. With eight assets in ongoing clinical trials and a robust preclinical pipeline, we are committed to advancing innovative therapies from discovery through clinical development.

Summary :

We are seeking an innovative Senior Scientist with industry experience in protein biochemistry, cell biology, and biologics drug development. In this laboratory-based role, you will be responsible for designing novel reagents, cell lines, and assays in support of functional screening of biologics leads. Furthermore, you will be executing display-based campaigns while interfacing with other members of the research team to achieve protein design goals. The position reports to the Director of Protein Engineering. The ideal candidate will have broad experience in one or more of the following fields : protein biochemistry, molecular biology, cell biology, immunology, and assay development.

Key Responsibilities :

  • Design and generate novel cell-based and biochemical assays as well as associated cell lines for use in functional screening of lead biologics (e.g. reporter assays for specific target signaling).
  • Develop and implement high throughput cell-free expression of antigens and Ab-based binder molecules for fast screening of lead molecules
  • Design and execute on display-based protein engineering campaigns of binder and effector molecules including affinity modulation, stability optimization, and development of novel properties (e.g. pH, epitope masking, etc.).
  • Optimize methods to efficiently execute functional screening and protein engineering campaigns (e.g. library generation and sample preparation, NGS sequencing, flow cytometry-based lead selection, etc.).
  • Design novel platforms for faster evaluation and screening of immune-based repertoires from immunized animal sources or display methods for use in both discovery and protein engineering campaigns.
  • Utilize data analysis tools to evaluate large datasets to inform iterative protein design.
  • Stay updated on advancements in instrumentation, software, and methodologies, currently utilized in high throughput screening and display-based protein engineering.
  • Troubleshoot technical issues and implement solutions to optimize lead molecules, ensuring data quality and integrity throughout the discovery and optimization process. Utilize LIMS system and maintain accurate and timely records and meet internal reporting standards.
  • Write and review Standard Operating Procedures (SOP), perform general laboratory duties, prepare experiment designs and execute data analyses.

Required Qualifications :

  • PhD (or equivalent) in bioengineering, biochemistry, structural biology, molecular biology, cell biology, or a related field. 3+ year industrial drug development experience preferred.
  • 2+ years of experience using generating novel cell lines and / or assay development
  • Experience in utilizing display technologies (yeast / phage) to discover and engineer novel binders and lead molecules of different classes (e.g. Ab, Fab, scFv, VHHs, etc.)
  • Extensive experience in FACS-based selection and sorting
  • Demonstrated proficiency in one or more of the following workstreams : library design and generation, display-based selection, protein engineering, and assay development
  • Experience with data analysis software (e.g., GraphPad Prism, FlowJo,) and statistical analysis of experimental results.
  • Excellent problem-solving skills, with the ability to troubleshoot technical issues and implement effective solutions
  • Outstanding organizational skills, attention to detail, and the ability to manage multiple projects simultaneously in a fast-paced environment
  • Strong communication and interpersonal skills, with the ability to collaborate effectively within multidisciplinary teams
  • On-site work is mandatory.
  • Work Environment :

    The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

    This individual will work in cell culture laboratory alongside other scientists and in a standard business office with desktop business equipment and a moderate noise level.

    Physical Demands :

    The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

    While performing the duties of this job, the employee is regularly required to sit for long periods of time. This individual must be able to operate standard laboratory and business equipment.

    The hiring pay range for this position is $90,000 - $140,000 per year based on skills, education, and experience relevant to the role.

    SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discovery or IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package.

    SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.

    Powered by JazzHR

    bQgRT3SjmI

    serp_jobs.job_alerts.create_a_job

    Senior Scientist • Redmond, WA, US

    Job_description.internal_linking.related_jobs
    Laboratory Research Scientist, Product development Analytical Biochemistry, Molecular Biology

    Laboratory Research Scientist, Product development Analytical Biochemistry, Molecular Biology

    ViomeBothell, Washington, United States, 98011
    serp_jobs.job_card.full_time
    Laboratory Research Scientist, Product development Analytical Biochemistry, Molecular Biology.Viome is a biotech company that analyzes clinical and molecular data using machine learning to develop ...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_30
    • serp_jobs.job_card.promoted
    Generative AI Scientist

    Generative AI Scientist

    VirtualVocationsEverett, Washington, United States
    serp_jobs.job_card.full_time
    A company is looking for a Generative AI Scientist.Key Responsibilities Deliver solutions to identify payment integrity issues and improve healthcare quality Develop exploratory data analysis ap...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_1_day
    • serp_jobs.job_card.promoted
    Senior Scientific Research Manager

    Senior Scientific Research Manager

    VirtualVocationsRenton, Washington, United States
    serp_jobs.job_card.full_time
    Scientific Research Project Manager.Key Responsibilities Plans, develops, leads, and executes mid- to high-level institutional and national projects in collaboration with the Principal Investigat...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_1_day
    • serp_jobs.job_card.promoted
    Scientist / Senior Scientist, Protein Design

    Scientist / Senior Scientist, Protein Design

    SystimmuneRedmond, WA, US
    serp_jobs.job_card.full_time
    SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its establi...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_30
    • serp_jobs.job_card.promoted
    Senior ML Scientist

    Senior ML Scientist

    VirtualVocationsKent, Washington, United States
    serp_jobs.job_card.full_time
    A company is looking for a Senior ML Scientist to develop automated methods for tagging data collected by autonomous vehicles. Key Responsibilities Design, implement, and deploy machine learning m...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_1_day
    • serp_jobs.job_card.promoted
    Supervisor - Laboratory

    Supervisor - Laboratory

    ProvidenceEdmonds, WA, United States
    serp_jobs.job_card.full_time
    Monitors the daily operation and staffing of the phlebotomy / processing staff, providing technical support, consistent training and quality assurance programs assuring appropriate collection proce...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_variable_days
    • serp_jobs.job_card.promoted
    • serp_jobs.job_card.new
    Senior Laboratory Assistant

    Senior Laboratory Assistant

    Providence Health and ServicesRenton, WA, US
    serp_jobs.job_card.full_time
    Represents the laboratory to the public, physicians, patients and offices while assisting laboratory technical staff,.Follows established departmental policies and procedures, objectives, safety; e...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_variable_hours
    • serp_jobs.job_card.promoted
    Research Scientist, Scientific Discovery

    Research Scientist, Scientific Discovery

    The Allen Institute for Artificial IntelligenceSeattle, WA, United States
    serp_jobs.job_card.full_time
    Persons in these roles are expected to work from our offices in Seattle.Our base salary range is $167,030 - $260,570, and in addition we have generous bonus plans to provide a competitive compensat...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_30
    • serp_jobs.job_card.promoted
    Freelance Biology Quality Assurance

    Freelance Biology Quality Assurance

    VirtualVocationsEverett, Washington, United States
    serp_jobs.job_card.full_time
    A company is looking for a Freelance Biology Quality Assurance (AI Trainer).Key Responsibilities Create and refine content to ensure accuracy and relevance in Biology Assess qualification tests ...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_1_day
    • serp_jobs.job_card.promoted
    Senior Laboratory Assistant

    Senior Laboratory Assistant

    ProvidenceEdmonds, WA, United States
    serp_jobs.job_card.full_time
    Represents the laboratory to the public, physicians, patients and offices while assisting laboratory technical staff, receiving / accessioning and / or processing specimens according to laboratory proc...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_30
    • serp_jobs.job_card.promoted
    Research Associate, RNA Biology

    Research Associate, RNA Biology

    GenScript / ProBioRedmond, WA, US
    serp_jobs.job_card.full_time
    About GenScriptGenScript Biotech Corporation (Stock Code : 1548.HK) is a global biotechnology group.Founded in 2002, GenScript has an established global presence across North America, Europe, the Gr...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_30
    • serp_jobs.job_card.promoted
    Propulsion Dev Lab Manager, Project Kuiper Propulsion

    Propulsion Dev Lab Manager, Project Kuiper Propulsion

    AmazonRedmond, WA, US
    serp_jobs.job_card.permanent
    Project Kuiper is Amazon's low Earth orbit satellite broadband network.Its mission is to deliver fast, reliable internet to customers and communities around the world, and we've designed the system...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_30
    • serp_jobs.job_card.promoted
    Lab Operations Manager, Kuiper Workplace Operations (KWO)

    Lab Operations Manager, Kuiper Workplace Operations (KWO)

    AmazonRedmond, WA, US
    serp_jobs.job_card.permanent
    Project Kuiper is Amazon's low Earth orbit satellite broadband network.Its mission is to deliver fast, reliable internet to customers and communities around the world, and we've designed the system...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_variable_days
    • serp_jobs.job_card.promoted
    Chemistry Tutors Jobs

    Chemistry Tutors Jobs

    Tutor MapEverett, Washington, US
    serp_jobs.job_card.full_time
    Tutor Map are offering new tuition and teaching positions in Everett.We are seeking Chemistry tutors and teachers in Everett. You can register for free, we take zero commission.Tutor Map is the larg...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_30
    • serp_jobs.job_card.promoted
    Project Manager Labs

    Project Manager Labs

    Cushman & WakefieldRedmond, WA, US
    serp_jobs.job_card.full_time
    Provides professional project management experience to designated projects and assignments at a client site, campus, and facilities. Interacts with client representatives onsite, receives direction ...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_30
    • serp_jobs.job_card.promoted
    Senior Scientist in Computational Biology

    Senior Scientist in Computational Biology

    VirtualVocationsSeattle, Washington, United States
    serp_jobs.job_card.full_time
    A company is looking for a Senior Scientist - Research Computational Biology (ARIA).Key Responsibilities Extract biological insights from complex omics and screening data to characterize disease ...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_1_day
    • serp_jobs.job_card.promoted
    Scientist

    Scientist

    Bio-Rad LaboratoriesWoodinville, WA, United States
    serp_jobs.job_card.full_time
    As a Scientist within our Global Assay Development Organization, you'll be an integral part of Bio-Rad's world class global R&D capability - focusing on biologics used in multiplex immunoassay tech...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_variable_days
    • serp_jobs.job_card.promoted
    Data Scientist, Trust & Safety

    Data Scientist, Trust & Safety

    VirtualVocationsRenton, Washington, United States
    serp_jobs.job_card.full_time
    A company is looking for a Data Scientist, Trust & Safety.Key Responsibilities Facilitate a zero-friction approach to email sending Investigate anomalies and gang attacks to identify root causes...serp_jobs.internal_linking.show_moreserp_jobs.last_updated.last_updated_1_day