IT Engineer

About Mandolin

Nearly every disease will become treatable in our lifetimes. Mandolin is laying the clinical and financial infrastructure to get groundbreaking treatments to patients faster, powered by AI agents.

Mandolin partners closely with the largest healthcare institutions in the US, covering more than $10B drug spend across the country. We're backed by Greylock, SV Angel, Maverick, SignalFire, and the founders of Vercel, Decagon, and Yahoo.

Why we need you

We’re scaling quickly, and our IT environment is becoming more complex by the week. We need you to design the systems and processes that will help us stay efficient, secure, and ready for what’s next—whether that’s onboarding new teammates, managing devices, or standing up new tools. You’ll play a critical role in keeping our growing team running smoothly.

What you’ll do

Partner with your manager and cross-functional teams to translate business and compliance requirements into secure, scalable IT solutions.

Own and maintain the company’s IT infrastructure — servers, networks, cloud environments, and end-user hardware — ensuring high availability and performance.

Define, document, and enforce IT and security policies across security, data protection, access control, acceptable use, procurement, and incident response.

Align IT systems and processes with Quality Management System (QMS) requirements, maintaining compliance with standards such as ISO, FDA, and HIPAA.

Implement and monitor security controls for endpoints, networks, and cloud environments — including vulnerability management, identity access, and threat detection.

Administer user accounts, permissions, and access in accordance with least-privilege and zero-trust principles.

Lead and deliver IT projects — from infrastructure upgrades to SaaS integrations — embedding security and QMS requirements throughout the lifecycle.

Provide advanced technical support and mentorship to employees, troubleshooting complex issues with speed and empathy.

Conduct periodic risk assessments, internal IT audits, and employee security awareness training.

Develop, test, and maintain disaster recovery and business continuity strategies.

Keep detailed, up-to-date documentation of IT architecture, configurations, and governance processes.

Partner with leadership to plan technology roadmaps, optimize costs, and ensure IT investments align with business objectives.

Must-have experience

5+ years in IT operations, infrastructure, or security engineering, with ownership of enterprise or startup environments.

Proven success building and scaling secure, reliable IT systems in fast-moving, resource-constrained settings.

Deep knowledge of cybersecurity best practices, network security, and system hardening.

Hands-on experience with IAM, endpoint management (MDM), and security monitoring or SIEM platforms.

Track record of designing and enforcing IT and security policies from the ground up.

Experience supporting IT components of Quality Management Systems (QMS) and regulated frameworks (ISO / FDA / HIPAA).

Strong analytical judgment and calm decision-making under pressure.

Excellent communicator who can collaborate effectively across engineering, compliance, and business teams.

Strategic, proactive mindset — balancing day-to-day support with long-term architecture and risk management.

Nice-to-haves

Experience supporting HIPPA and SOC 2 readiness or certification efforts.

Prior experience in early-stage or high-growth startups.

Familiarity with automation and scripting for IT operations (e.g., Bash, PowerShell, Python).

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