Process Chemistry Senior Principal Scientist

Job Description

General Summary

The successful candidate will possess a deep knowledge of process chemistry skills for the development of synthetic routes, with early and late-phase development experience and delivering drug substance under tight timelines. They will have a strong interest in laboratory work and will be key to driving the development of safe and scalable chemistry. They will spearhead the advancement of Vertex's portfolio through personal laboratory effort as well as overseeing internal and external resources. They will leverage additional Vertex resources (high-throughput experimentation, engineering and material sciences, process safety, analytical, etc.) to assist in identifying and optimizing reaction conditions for key transformations. The successful candidate will represent process chemistry in cross-functional teams requiring good communication skills. The successful candidate will have accountability for creating and developing a synthetic route to deliver active pharmaceutical ingredients (APIs) within a specification range fit for the phase of development and delivering the technology and materials to enable candidate progression through development. The Sr. Principal Scientist Process Chemistry will lead / participate in cross-functional technical teams within their field of expertise. They will also be responsible for mentoring internal process chemistry scientists and promote the department through publications in peer reviewed journals and participation in external conferences.

Key Responsibilities

• Demonstrates advanced intellectual and technical leadership
• Familiar with early and late phase pharmaceutical development and regulatory expectations
• Work with Pharm Sci team to develop project strategy, timelines, and leverages technical skills as a Process Chemistry expert within Vertex.
• Individual lab work focused on developing safe, scalable processes
• Seek to employ state-of-the art technologies, including flow chemistry, photochemistry, electrochemistry, computational and predictive tools
• Will contribute directly to technology transfer to internal sites or external vendors
• Proactively identifies and oversees vendors to gain access to technologies as needed to deliver pipeline
• Leverage cross-functional knowledge to guide pharmaceutical sciences teams on potential impact of decisions
• Assesses data integrity to provide expert interpretation and recommendations to project teams and leadership
• Presents synthetic and experimental plans clearly and persuasively to all parts of the organization.
• Recognized as a technical leader by the group and may mentor junior staff
• Authors publication, patent, and regulatory submissions

Knowledge and Skills

Education and Experience

Pay Range

$153,600 - $230,400

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

On-Site Designated

Flex Eligibility Status

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note : The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and / or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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