Prellis Biologics uses proprietary technology to 3D print lymph node organoids, which we are using to generate in vitro antibody libraries and in vitro human lymph node cocultures for generating antigen-specific B-cells.
We are seeing a Sr. Scientist to join our Antibody Screening team. This role will be responsible for developing a robust protein production pipeline and generating protein conjugations to support the externalized immune system (EXIS) workflows.
The successful candidate will have a strong background in protein chemistry and bioconjugation techniques.
Key Responsibilities :
Perform molecular biology techniques, including but not limited to, plasmid vector design and construction, fragment design, recombinant cloning, and high-throughput PCR
Develop a robust production workflow for reagent development implement and refine techniques for scalable protein production in various expression systems (e.
g. bacterial, insect, mammalian cells)
Develop protein purification and QC protocols, including but not limited to, FPLC, HPLC, SDS-PAGE, and MS, for new reagents that are developed
Synthesize and purify protein conjugates to support EXIS workflow development. This may involve conjugating small molecules, fluorophores, and biomolecules to proteins of interest
Collaborate with internalteams to test the performance of protein conjugates and other reagents that are developed. Troubleshoot issues as needed
Document standard operating procedures (SOPs) for assays and reagent preparations. Maintain detailed experimental records
Experience with NGS and sequence analysis is a plus
Experience with immunogen design is a plus
Experience with flow cytometry techniques is a plus
Skills and Experience :
Ph.D. in Chemistry, Biochemistry, Chemical Engineering, or Bioengineering with a strong academic record. Outstanding M.S.
candidates with relevant experience will be considered. Must have 3-5 years of revelent industry experience.
Hands-on experience with analytical techniques such as SPR, Octet, ELISAs, UV-Vis spectroscopy, fluorescence spectroscopy, and liquid chromatography is desired.
Rigorous scientist with a recordof designing and executing carefulexperiments, maintaining detailed experimental records, and developing robust, transferrable processes.
Strong written and oral communication skills.
Able to thrive in a dynamic,collaborative start-up environment.
Sr. Air Quality Engineer/Scientist (Consulting)
Air Quality Engineer/Scientist (Environmental Permitting and Compliance). Our team has over 1,000 years of combined environmental experience and consists of engineers and scientists that specialize in Air Quality, Waste, Water, CEQA, Safety, and Industrial Hygiene. Our team has over 1,000 years of c...
Sr. Data Scientist - GenAI & LLMs
Read on to fully understand what this job requires in terms of skills and experience If you are a good match, make an application.While candidates in the Bay Area are strongly preferred.The Machine Learning (ML) Practice team is a specialized customer-facing ML team at Databricks facing an increasin...
Sr. Staff Data Scientist, Core Ecosystem
We are looking for a Senior Staff Data Scientist for Ecosystem. ...
Research Scientist (Staff / Sr Staff) - Power Markets
As a key member of our sciences group, you will play an active role in a) cultivating our culture of experimentation, insights discovery, and incremental delivery, b) facilitating research into state of the art operations research & optimization techniques, c) helping to identify, recruit, train...
Sr. Data Scientist, Marketing Analytics - LTV
As the Data Scientist, you will be a partner to the Marketing and Finance teams by providing data-driven insights through ad-hoc analyses, presentations, automated reports and dashboards, experiment design, and advanced statistics research and development. Be an advisor for other Data Scientists on ...
Sr. Scientist
Rigorous scientist with a recordof designing and executing carefulexperiments, maintaining detailed experimental records, and developing robust, transferrable processes. ...
Sr. Scientist - Clinical Biomarker (small molecule)
You'll be responsible for conducting essential activities for clinical drug development by supporting the development of biomarker assays for evaluating small molecule drug candidates.You'll also ensure methods are developed, validated, and executed while maintaining records of assay performance, cl...
Sr. Data Scientist
The Adobe Digital Imaging Data Science Team (Photoshop & Lightroom) is looking for a Data Scientist who is passionate about data and has the desire to provide an outstanding product experience for our customers. ...
Sr. Data Scientist (Operations)
As the Senior Data Scientist, you will lead initiatives targeted to drive efficiency, scalability, and operational performance using AI/ML. You will serve as subject matter expert on AI/ML in Operations and eventually cultivate a team of Data Scientists to deepen our strength in this space. ...
SR. Environmental Project Manager- Scientist/Engineer
Become part of our global network of skilled engineers, scientists, auditors, planners and environmental specialists, all working together to leave this world better than we found it. Senior Environmental Project Manager- Scientist/Engineer. ...