Principal Scientist - In Vivo Immunology

Principal Scientist, In Vivo Immunology

If the following job requirements and experience match your skills, please ensure you apply promptly.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade.

R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

The Principal Scientist in the In Vivo Immunology team will serve as the preclinical in vivo study lead and will represent the project team in spearheading GSK’s innovation of novel viral vaccines and platform programs.

You will have the opportunity to lead the in vivo efforts on multiple viral vaccine programs and platforms within GSK and with external partners in a collaborative and matrix team.

You will design and write in vivo study protocols, coordinate and initiate preclinical studies, conduct and analyze experimental results pertaining to the understanding of cellular mediated immune response and humoral immune response from novel vaccine candidates, formulations, and RNA platforms.

Key Responsibilities :

• Design, plan, conduct, coordinate, monitor, and analyze in vivo murine studies for vaccine and platform programs.
• Implement and ensure adherence to GSK and regulatory requirements for compliance with IACUC guidelines through writing and reviewing in vivo study protocols and participating in the independent scientific review committee.
• Conduct dosing, IVIS imaging, necropsy, and tissue harvest from animal studies and supervise technicians conducting these activities.
• Perform experiments characterizing cell-mediated immune response for preclinical immunogenicity or challenge studies using flow cytometry, ELISPOT assays and others.
• As a preclinical in vivo study lead, you will work in a matrix team to support the identification of novel vaccine candidates and support platform development.
• Prepare and document study protocols and final reports for projects as an author.
• Contribute to patent filing, IND submissions, and scientific publications.
• Present study plans and results at project meetings.
• Develop new experimental techniques based on project needs.
• Mentor and train junior scientists.

The successful applicant will spend 2-6 months within the first year in Rockville, MD to support and guarantee a smooth transition of methods and know-how to the new laboratories in Cambridge, MA.

Basic Qualifications :

Ph.D., M.S., or B.S. degree in immunology or a related field. The required post-graduate work experience is 4+ years for a Ph.

D., 8+ years for an M.S., and 10+ years for a B.S.

• Three or more years of experience in conducting in vivo animal studies within the fields of vaccines, infectious diseases, or immunology.
• Three or more years of experience in small rodent handling and drug administration, in-study blood sampling, necropsy, tissue harvest, and processing.
• Three or more years of experience in designing, executing, and analyzing cell-mediated immune response readouts using conventional or spectral flow cytometry.

Preferred Qualifications :

• Matrix management experience. A collaborative team player with strong interpersonal skills to work with diverse groups within the organization.
• Excellent communication and writing skills.
• Detail-oriented with the agility to balance multiple projects.
• Extremely organized with experience in documentation of study protocols and reports.
• Experience with immune-response related readout methods such as ELISPOT, Luminex, and qPCR methodologies.

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