Scientific Director, Toxicology Development Biological Sciences (nonclinical)

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow.

We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio.

For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

AbbVies Development Biological Sciences department is seeking a Scientific Director for its Portfolio Leadership Group. The primary function of this role will be to serve as a nonclinical safety representative for assigned molecules across AbbVies diverse portfolio.

As a safety representative, the Scientific Director will be responsible for the overall strategy and execution of the nonclinical toxicology program, collaborating cross-functionally with project leads, providing data interpretation at various internal and external venues, and authoring regulatory documents.

The ideal candidate will have 10+ years of experience in the area of nonclinical safety within the pharmaceutical industry.

He / she should have the experience and ability to develop drug candidates from discovery through marketing. This senior-level position is expected to have a high impact contributing scientific expertise in nonclinical safety assessment, knowledge of industry best practices and pertinent regulatory guidelines, and a vision of future enhancements in the field.

This position is located at our headquarters in Lake County, IL, just north of Chicago and will be expected on-site, minimally, 3 days a week.

Essential Responsibilities :

• Serve as an active member for multi-disciplinary project teams as a nonclinical safety functional area subject matter expert.
• Articulate and communicate non-clinical safety strategies and provide development plans for multiple drug modalities including but not limited to small molecules, biologics, ADCs, and / or cell and gene therapies, across various therapeutic areas including but not limited to oncology, neuroscience, and immunology.
• Participate in due diligence reviews of drug products to identify potential risks and provide recommendations for partnership or in-licensing.
• Author and submit regulatory documents (IBs, INDs / CTAs, NDAs / BLAs, regulatory queries) and interact with regulatory agencies (US and ex-US) as needed.
• Generate impurity, excipient and metabolite risk assessments as necessary during the life cycle of a drug candidate.
• Support and mentor others as it pertains to drug development and the execution of the portfolio, with an emphasis on the nonclinical aspects.
• Participation in pharmaceutical industry consortia related to nonclinical aspects of drug development

Qualifications

• PhD or DVM required
• 10+ years of relevant experience in pharmaceutical industry leading nonclinical safety programs
• Experience authoring relevant regulatory documents and responding to requests from regulatory agencies
• Deep expertise in a particular therapeutic area or modality (e.g. gene therapy) is a benefit, but not required
• General awareness and understanding of drug metabolism and pharmacokinetics and its interplay with safety (e.g. MIST, drug-drug interactions, toxicokinetics, anti-drug antibodies...) is a plus.
• Skilled in project / program management and leadership
• General computer skills and knowledge of the Microsoft applications including but not limited to Microsoft Word, Excel, and PowerPoint

Leadership Attributes :

• Ability to anticipate, recognize and resolve scientific and technical problems that are encountered during various phases of drug development
• Strong communication and presentation skills
• Ability to work in collaboration with other functional areas and within a matrix organization.

LI-Onsite

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law :

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position.

Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range.

This range may be modified in the future.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical / dental / vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.
• This job is eligible to participate in our long-term incentive programs.

Note : No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.

It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

US & Puerto Rico only - to learn more, visit https : / / www.abbvie.com / join-us / equal-employment-opportunity-employer.html