Scientist I/II - Oligo Purification

Our client develops, manufactures and supplies a wide array of innovative medical diagnostic products, services, tests, platforms and technologies.

Job Summary :

Conduct purification and characterization of oligonucleotides utilizing established and published procedures.

Duties (Scientist I or Scientist II) :

• Purification and characterization of oligonucleotides utilizing established and published procedures, and technical and theoretical understanding.
• Assumes responsibility for the accuracy, quality, and timeliness of oligo purification and analysis results.
• Maintains lab supplies and various purification analytical instruments.
• Summarizes experimental results, and reviews conclusions with supervisor / manager.
• Works with oligo synthesis personnel to ensure smooth handoff of oligos from DNA Synthesis to Oligo Purification.
• Keeps supervisor / manager informed of project status, particularly of significant findings and results in critical problem areas.
• Performs work according to established internal safety guidelines and procedures, and as specified by appropriate external regulatory agencies (e.g., OSHA).
• Works with supervisor / manager to prioritize orders. Delivers completed orders and interfaces with customers for oligo orders.
• Assumes accountability for own lab notebook documentation and documentation of oligo orders made, ensuring purification records and results are recorded timely, accurately and consistently, and according to established formats.
• Participates in routine lab maintenance, lab safety, ISO, and QSR implementation. Troubleshoots issues related to instrumentation.
• Sets up, maintains, and runs oligo purification instruments to make oligos according to standard protocols and current priorities.
• Purify oligos in an efficient, timely, and cost effective manner.
• Prioritize, schedule, and complete oligo purification to accommodate special RUSH or repeat orders. Batches the orders in the manufacturing process when there are infrequent orders such that there is a balance between manufacturing efficiency and reasonable turnaround times.
• Manufacturing Support : Helps maintain the lab / reagent supplies in the lab to ensure that there is no manufacturing downtime.

Helps keep the lab and work areas clean and safe. Perform routine analyses (HPLC, LCMS, and / or UV spectral) on oligos on as needed basis.

Documentation : Responsible for ensuring capture of lab data from instrumentation in SDMS / electronic notebook in a timely manner.

Compiles and prepares data for statistical, scientific analyses, reports, or for presentations.

Qualifications :

• Scientist I :
• Bachelor's degree in Chemistry, Biochemistry, Biological / Life Sciences, or related field, or equivalent combination of education and work-experience
• Minimum 0 to 3 years related experience, preferred 1-3 years experience in oligonucleotide manufacturing.
• Scientist II :
• Bachelor's degree in Chemistry, Biochemistry, Biological / Life Sciences, or related field, or equivalent combination of education and work-experience.
• Minimum 2 to 3 years related experience, preferred 4-5 years experience in oligonucleotide manufacturing.
7 days ago