Research Associate II, Lung Biology

Who We Are :

A variety of soft skills and experience may be required for the following role Please ensure you check the overview below carefully.

ReCode Therapeutics is a clinical-stage genetic medicines company using precision delivery to power the next wave of mRNA and gene correction therapeutics.

ReCode's proprietary Selective Organ Targeting (SORT) lipid nanoparticle (LNP) platform enables highly precise and targeted delivery of genetic medicines directly to the organs, tissues and cells implicated in disease, enabling improved efficacy and potency.

ReCode's lead programs include RCT1100 for the treatment of primary ciliary dyskinesia caused by pathogenic mutations in the DNAI1 gene, and RCT2100 for the treatment of the 10-13% of cystic fibrosis patients who have Class I mutations in the CFTR gene and do not respond to currently approved CFTR modulators.

RCT1100 and RCT2100 are inhaled disease-modifying mRNA-based therapies formulated using the SORT LNP delivery platform. ReCode is expanding its pipeline to develop potential therapies for other rare and common genetic diseases, including musculoskeletal, central nervous system, liver and infectious disease indications.

Summary of Position :

We are seeking a highly motivated individual to join our Lung Biology team, focusing on the development of potency assays.

The primary responsibilities of this role include planning, performing, and analyzing experiments to support the discovery and development of potency assays for various programs.

The successful candidate will collaborate with an interdisciplinary team at ReCode, particularly with CMC, during assay development and transfer to CROs.

This position is lab-based in Menlo Park.

Responsibilities :

• Perform cell culture work, including thawing, maintaining, expanding, cryopreserving immortalized cell lines and primary cells.
• Plan and execute cell-based assays like Immunofluorescence, western blot, JESS, ELISA, qPCR.
• Actively engage in the creative development of functional potency assays tailored to specific program needs.
• Prepare aliquots of media, PBS, antibodies, supplements, and inventory management.
• Strictly follow protocol and maintain accurate documentation for regulatory submissions.
• Coordinate with fellow researchers within the team or with CMC for assay planning and execution.
• Participate in method transfer followed by method qualification and validation.
• Plan and perform experiments and analyze data with supervision.
• Present data at group meetings.
• Contribute to lab management activities.

Qualifications :

• Bachelor's degree with 4+ years or master's degree in biology or a related field, along with 2+ years of laboratory experience in the biopharma industry.
• Proven hands-on experience with sterile technique for handling and growing mammalian cell lines.
• Demonstrated experience with techniques such as protein extraction, western blot / JESS, immunofluorescence, qPCR, and cell-based assay development.
• Strong protocol adherence and good documentation skills are a must. Work experience in GxP settings is a plus.
• Ability to work independently and in a team-oriented environment to meet project goals and timelines.
• Good verbal and written communication skills.
• Strong troubleshooting and problem-solving skills are important.
• Desire to work in a fast-paced environment.

Salary Range : *$80,000-$85,000 / year

Benefits Offered for Full-Time Employees :

• No premium cost for employees - 100% subsidized by ReCode for full-time employees
• Company 401k contribution
• 15 days of company paid holidays, including a holiday shutdown (usually the last week of the year)
• Mental health support for employees & their families
• FSA available, including a lifestyle spending account subsidized by company
• Employee discounts at hotspots

ReCode Therapeutics (www.recodetx.com) offers a competitive compensation / benefits package with a friendly, collaborative culture that values employee engagement and ongoing career development.

ReCode Therapeutics is an Equal Opportunity Employer.

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