Assistant Principal Scientist, Protein Drug Product Development

Company Description :

Insmed is a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases.

Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion.

Guided by our core values of collaboration, accountability, passion, respect, and integrity, we aim to foster an inclusive, diverse, and flexible work environment, where our employees are recognized for leaning in and rolling up their sleeves.

If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career.

Recognitions :

Consistently Ranked Science’s Top Employer

Insmed is dedicated to creating a collaborative environment where our team can thrive. Every day, our employees turn their passion for science and research into innovative solutions for patients.

That’s why we’ve been named the No. 1 company to work for in the biopharma industry in Science’s Top Employers survey for four years in a row.

A Certified Great Place to Work®

We believe our company is truly special, and our employees agree. In July 2024, we became Great Place to Work-certified in the U.

S. for the fourth year in a row. We are also honored to have been listed on the Best Workplaces in Biopharma™, Best Workplaces in New York™, PEOPLE® Companies That Care, Best Workplaces for Women™, Best Workplaces for Millennials™, and Best Medium Workplaces™ lists.

Overview :

Insmed’s Research team is seeking an experienced candidate to spearhead drug product formulation and process development, biophysical characterization, stability evaluation, and tech transfer of cutting-edge biotherapeutic candidates.

Responsibilities :

Lead biotherapeutic drug product discovery / engineering activities across different therapeutic areas.

Utilize protein biochemistry / biophysical techniques to inform on optimization of formulation and process to support development candidate nomination.

Evaluate, select, and apply standard engineering procedures to process design and lead tech transfer activities.

Present findings in internal and external meetings; author technical reports and publications.

Communicate with internal and external partners to progress projects.

Position Requirements (Required and / or Preferred Skills, Experience, and Education) : PhD in Biochemistry, Molecular Biology, Biotechnology, Enzymology, Chemical Engineering, Bioengineering, or a related field with 6+ years or MS with 10+ years of relevant hands-on experience.

Solid understanding of molecular biology, cell biology, and protein biochemistry.

Experience developing formulations and processes to stabilize protein therapeutics.

Protein production experience using prokaryotic and eukaryotic host systems.

Experience using automated chromatography workstations (e.g., AKTA FPLCs) and employing multi-dimensional purification strategies.

Experience using analytical techniques to characterize proteins including light scattering (e.g., DLS, SEC-MALS), mass photometry, circular dichroism, and thermal stability (e.g., DSC, DSF).

Experience investigating biotherapeutic half-life extension is a plus.

Target affinity characterization experience (e.g., ITC, SPR, BLI) is a plus.

Experience with crystallization techniques (e.g., co-crystallization, seeding, soaking, etc.) and interpreting crystallographic data is a plus.

Familiarity with chemistry and protein computational techniques is a plus.

A record of scientific publication employing the skills listed above.

Experience leading functions and teams is a plus.

Familiarity with experiment documentation using electronic lab notebook.

Strong written and oral communication skills are required.

Applicants should be detail-oriented, highly organized, and able to multi-task with multiple projects.

Must successfully exhibit Insmed’s five (5) core values of Collaboration, Accountability, Passion, Respect, and Integrity along with any other position specific competencies.

Individuals must demonstrate the ability to interact successfully in a dynamic and culturally diverse workplace.

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Salary Range :

$127,000 - $178,533 a year

Compensation & Benefits :

We’re committed to investing in every team member’s total well-being, now and in the future. We offer a competitive total-rewards package to all employees around the world, including :

Flexible approach to where and how we work, regionally based

Competitive compensation package including bonus

Stock options and RSU awards

Employee Stock Purchase Plan (ESPP)

Flexible Vacation Policy

Generous paid vacation schedule and winter break

ADDITIONAL U.S. BENEFITS :

401(k) plan with company match

Medical, dental, and vision plans

Company-provided Life and Accidental Death & Dismemberment (AD&D) insurance

Company-provided short and long-term disability benefits

Unique offerings of pet, legal, and supplemental life insurance

Flexible spending accounts for medical and dependent care

Accident and Hospital Indemnity insurance

Employee Assistance Program (EAP)

Mental Health on-line digital resource

Well-being reimbursement

Paid leave benefits for new parents

Paid time off to volunteer

On-site, no-cost fitness center at our U.S. headquarters

Additional Information :

Insmed Incorporated is an Equal Opportunity / Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source.

Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities;

please contact us directly to be considered for a formal agreement.

Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities.

To request reasonable accommodation to participate in the job application or interview process, please contact us by email at and let us know the nature of your request and your contact information.

Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.